Show cover of Impulse - Meeting Healthcare Pioneers

Impulse - Meeting Healthcare Pioneers

Impulse is the podcast where we dive into the most exciting breakthroughs in healthcare of our time. In each episode, we sit down with some of the brightest minds who are using technology to rethink the way we care!

Titres

#28 - Modeling embryos to understand early life - Jacob Hanna - Weizmann Institute of Science
Because of ethical and medical challenges, early human embryo development remains “a black box” to us, as Prof. Jacob Hanna himself puts it. Despite all the progress made in medicine over the past decades, there is still a whole lot to learn about the causes of miscarriages, infertility, or early developmental defects. In 2023, Jacob’s group from the Weizmann Institute of Science published a pivotal paper in Nature that redefines how we study developmental biology, with the potential to accelerate our understanding of early human life. Their achievement? The creation of the first synthetic embryo model closely resembling a day-14 fetus, obtained “ex utero” without gametes and outside a womb. A human embryo model derived from “naive” stem cells in the lab, which can be obtained from “adult” cells that make up our body (like skin cells for instance). A technology that could generate embryo models of ourselves based on a simple cell sample. This work had an unprecedented impact on the scientific community and the general public, being named by TIME Magazine as one of the 100 best inventions of 2023. A breakthrough that raises important ethical, technical, and legal questions. I had the honor of meeting Jacob for this episode of Impulse, with whom we discuss the functioning of this fascinating technology, its potential medical applications in the future, and the key societal questions it raises. A conversation where we dive into the magic of human development, with a stellar scientist and advocate for responsible scientific research! Timeline: (00:02:58) - Jacob’s journey from his medical practice to studying developmental biology (00:06:09) - Why we know so little about early human development (00:08:45) - Jacob’s lab breakthrough in modeling human embryos (00:16:20) - Reprogramming cells to their “naïve” state (00:18:09) - Dealing with your research being put under the spotlight (00:20:02) - The “recipe” to create human embryo models without gametes and outside a womb (00:27:22) - Ethical considerations and how far we can go with this technology (00:35:15) - Potential medical applications for the future (00:38:05) - Jacob’s role as an adviser to the startup Renewal Bio What we also talked about with Jacob: Prof. Shinya Yamanaka (2012 Nobel Prize in Physiology or Medicine with Prof. John Gurdon) Induced pluripotent stem cells (iPSCs) Embryonic stem cells International Society for Stem Cell Research (ISSCR) Taledomide We cited with Jacob some of the past episodes of the series:: #23 - Disrupting the smart wearables industry - Leo Grünstein - Spiden As mentioned by Jacob during the episode, we recommend the book “The Master Builder” by Prof. Alfonso Martinez Arias, challenging the traditional thinking where cells (and not DNA) may hold the key to understanding life’s past and present. Feel free to follow the Weizmann Institute of Science on LinkedIn. You can contact Jacob via email and follow his activities on LinkedIn, X, and Facebook! If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and kept posted on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
48:16 07/05/2024
[EXTRACT] - Jacob Hanna on the ethical implications of human embryo models
To discover the whole episode type "#28 - Modeling embryos to understand early life - Jacob Hanna - Weizmann Institute of Science" on your streaming platform.
04:13 07/05/2024
#27 - Reinventing neuroelectronic therapies - Carolina Aguilar - Inbrain Neuroelectronics
We are at a turning point for brain-computer interfaces (BCIs) and neurotechnology. We have all witnessed phenomenal progress in this field recently via images shared by Neuralink, showing paralyzed patients who can communicate with a computer through their own thoughts. Other fascinating applications, such as those being worked on by Gregoire Courtine and Jocelyne Bloch, enable paraplegics to regain an unprecedented degree of walking mobility. These advancements are mind-blowing and illustrate the potential of these technologies to address conditions that have a major impact on quality of life. What if we were to enhance the physical properties of these implants while making them more accessible in terms of costs to health systems? Where could this paradigm shift take us, and what prospects could it open up for treating complex neurological disorders? This is what we explore in this episode with Carolina Aguilar, CEO of Inbrain Neuroelectronics, a company developing a cutting-edge neural platform based on graphene, promising to change the way we decode, modulate, and stimulate neuronal activity. We talk with Carolina about: How Inbrain Neuroelectronics' technology enhances the resolution of BCIs and their therapeutic potential The stakes around BCIs and their promise in treating serious neurological disorders The importance of focusing their development around therapeutic indications vs. aiming for human augmentation The commercialization of these solutions through a value-based care approach and key success factors Empowering women in science and business An outlook on the future of brain therapies that bridges the gap between reality and science fiction! Timeline: (00:03:22) - Explaining Inbrain Neuroelectronics’ neural platform (00:07:32) - The medical need for BCIs and the first indications targeted by Inbrain Neuroelectronics (00:18:46) - Risks around BCIs and ethical considerations for the field to head in the right direction (00:26:17) - Toward value-based commercial models for BCIs (00:29:40) - Transitioning from Medtronic to an early-stage Medtech startup (00:33:29) - Empowering women in science and business What we also talked about with Carolina: Neuralink Elon Musk Sapiens Steering Brain Stimulation Medtronic ONWARD Medical Precision Neuroscience Paradromics Synchron Neurosoft Bioelectronics We cited with Carolina some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore As mentioned by Carolina during the episode, you can access Inbrain Neuroelectronics’ publications here and learn more about their ongoing research and therapy development efforts. You can listen to the Neurotech Pub podcast hosted by Matt Angle here. Feel free to follow Inbrain Neuroelectronics activities on LinkedIn. If you want to contact Carolina, you can reach out to her over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a monthly newsletter around the podcast where you will be informed of the latest episodes and updated on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
45:12 07/04/2024
[EXTRACT] - Carolina Aguilar on the future of neurotechnology
To discover the whole episode type "#27 - Reinventing neuroelectronic therapies - Carolina Aguilar - Inbrain Neuroelectronics" on your streaming platform.
03:01 07/04/2024
#26 - Redefining allergy care - Kenneth Chahine - Nectar Life Sciences
Many of us struggle with allergies, usually something we’ve been dealing with our whole life, either continuously or episodically. Be it related to food, pollen, dust, pets, or many others, it’s quite a pain and it can take us away from many things we appreciate in life. And I deliberately include myself in this group. Somehow it was engraved in my brain as a condition one needs to cope with, without much opportunity for improvement. It turns out companies like Nectar Life Sciences are redefining the way we detect and treat allergies from the comfort of our homes. Based on the latest science in this field, and backed by his extensive experience in consumer healthcare, Kenneth Chahine and his team are transforming the experience of allergy care for patients, offering a convenient and personalized approach to it. In this revealing episode, we talk with Kenneth about: The inconvenience of past approaches to allergy detection and treatment How allergy immunotherapy works and can be delivered through a few drops delivered to the tongue How Nectar Life Sciences enables personalized allergy immunotherapy for patients The transformative power of preventing acute allergic shocks Lessons learned from a serial healthcare entrepreneur at the interface of genetics, biochemistry, and intellectual property A conversation with a tireless figure in healthcare entrepreneurship, shedding light on one of the largest chronic conditions globally and how it can be tackled in a modern way! Timeline: 02:28 - Kenneth’s background at the interface of genetics, biochemistry and intellectual property 04:14 - The global burden of allergies as a chronic condition 05:53 - Origins of allergies 07:49 - Immunotherapy or how to train your immune system to be desensitized to allergens 09:43 - Detecting which allergens you are sensitive to 11:17 - How Nectar Life Sciences approaches allergy treatment 22:11 - Kenneth’s mindset toward solving complex healthcare challenges in new ways 26:01 - Opportunities beyond allergy care 32:16 - Kenneth’s advice to fellow healthcare entrepreneurs What we also talked about with Kenneth: Avigen Ancestry Anaphylaxis Neurimmune University of Utah We cited with Kenneth some of the past episodes from the series: 15 - Propelling diagnostics through miniaturization - Nicolas Durand - Abionic As mentioned by Kenneth during the episode, you can access Nectar Life Sciences’ Learning Hub here and learn more about Prof. Edwin H. Kim’s research there. Feel free to follow Nectar Life Sciences activities on Instagram, Facebook, and TikTok! If you want to contact Kenneth, you can reach out to him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a monthly newsletter around the podcast where you will be informed of the latest episodes and updated on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
45:40 04/02/2024
[EXTRACT] - Kenneth Chahine on being dogmatic about improving allergy care
To discover the whole episode type "#26 - Redefining allergy care - Kenneth Chahine - Nectar Life Sciences" on your streaming platform.
04:06 04/02/2024
#25 - Stopping a bleed in three seconds - Joe Landolina - Cresilon
We don’t need to look far in the daily news to understand the stakes and the importance of having efficient solutions to control and stop bleeding. In the times we live in, where the world is crippled by a series of humanitarian catastrophes (some of natural origin, some of human origin), technological wonders from the medical field make me truly hopeful about the future, and about what we can achieve as humans. One of them is the hemostatic gel - a gel that can stop bleeding - that Joe Landolina and his team at Cresilon created. And its astonishing performance is easy to grasp: any bleed can be stopped within three seconds. Compared to traditional methods that require several minutes, it can mean the difference between life and death. There’s so much that impresses in Joe’s journey since the foundation of Cresilon: the fact that he developed the gel formulation himself, that he founded the company at 17 years old in his first year at University, or that Cresilon now represents the largest biotech manufacturing site in New York, and so much more! Beyond these successes, this episode is an ode to biomimicry and the science of biomaterials. Joe reveals everything about the functioning of this revolutionary medical product, its ability to stop bleeding almost instantly, and what it changes in medicine for the treatment of superficial injuries, but especially for the most severe traumatic cases. A surprising encounter with a prodigious entrepreneur, building his path on resilience and adaptability, with the long-term vision to transform bleeding control in humans! Timeline: 02:23 - Joe’s background and founding Cresilon in his first year in college 06:15 - Cresilon’s mission and the technology at its core 08:42 - How the hemostatic gel from Cresilon compares to traditional bleeding control methods 10:40 - The explanation behind Cresilon’s hemostatic gel unique performance 16:06 - How the gel is applied and removed 21:44 - Marketing first the product for veterinary application before moving to human use 25:27 - Being the only biotech company with manufacturing capabilities in New York 34:15 - Setting up the company to become a large medtech player in the long term What we also talked about with Joe: New York University Columbia University Scar tissue formation Fibrin Extracellular matrix Hurricane Sandy American Veterinary Medical Association Roche Pfizer Cutiss We cited with Joe some of the past episodes from the series: 18 - The dark genome as the next revolution in drug discovery - Samir Ounzain - HAYA Therapeutics Feel free to follow Cresilon’s activities on LinkedIn! You will find here the TED Talk that Joe held in 2015, and here the Medsider podcast episode between Joe and Scott Nelson that we mention in this episode of Impulse. If you want to contact Joe, you can reach out to him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and updated on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
45:27 12/11/2023
[EXTRACT] - Joe Landolina on the criticality of rapid bleeding control in medicine
To discover the whole episode type "#25 - Stopping a bleed in three seconds - Joe Landolina - Cresilon" on your streaming platform.
03:41 12/11/2023
#24 - Reimagining male contraception - L.R. Fox - NEXT Life Sciences
How would the world look like if men had the most efficient and reversible means of birth control? The outstanding work that L.R. Fox and his team at NEXT Life Sciences are leading might bring a very tangible answer to this question. Based on the pioneering work from Prof. Sujoy K. Guha and The Parsemus Foundation, they are developing one of the most promising male birth control methods medicine has ever known, under the name of Plan A. As an American citizen who has grown under the Foster Care program, Fox (as he likes to be called) has witnessed firsthand the dramatic consequences that unplanned pregnancies can have on individuals and their relatives in the long term. According to him, we have gone quite far already in terms of available options for women and men when it comes to birth control methods. But Plan A could be a revolution in the space, as it is completely hormone-free, painless to deliver and revert, and has an efficacy duration that is way beyond current standards. And most importantly, it can redistribute the heavy responsibility of family planning from women to men. In this episode, we talk about the science behind Plan A, where the technology comes from, how far is it from being available worldwide, and what it would change for society as a whole! A fascinating conversation with a visionary founder, deeply led by the purpose of fostering a positive impact in the world, and with a strong social approach to entrepreneurship! Timeline: 02:35 - Fox’s background and how he landed in the field of male contraception 06:16 - Experiencing firsthand the consequences of unplanned pregnancies 09:34 - The mission of NEXT Life Sciences 11:50 - The need, the science, and the functioning of Plan A 16:02 - How the Plan A procedure works and gets reverted 25:02 - Guaranteeing a 10-year efficacy claim 26:56 - Launching the first human clinical trials 33:55 - Making it accessible to the broadest population 38:17 - The philosophy of Fox and NEXT Life Sciences What we also talked about with Fox: Sexually transmissible diseases (STDs) Condoms Vasectomy Reversible inhibition of sperm under guidance (RISUG) Plan B Public benefit corporation We cited with Fox some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore You can learn more about NEXT Life Sciences through their website, and feel free to follow their activities on LinkedIn! As mentioned by Fox during the episode, you can learn more about Plan A on the dedicated website as well as on Instagram, X, Facebook, and TikTok. If you want to contact Fox, you can reach out to him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and updated on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
49:46 18/10/2023
[EXTRACT] - L.R. Fox on the next generation of male contraceptives
To discover the whole episode type "#24 - Reimagining male contraception - L.R. Fox - NEXT Life Sciences" on your streaming platform.
02:33 18/10/2023
#23 - Disrupting the smart wearables industry - Leo Grünstein - Spiden
Wearables are a form of technology that has rapidly become a part of our lives over the past 15 years, with the introduction of devices from Fitbit, Apple, Samsung, and others to the market. Initially informing us about our heart rate and daily step count, they have evolved to incorporate increasingly sophisticated features, allowing us to track our sleep relatively accurately, monitor our overall physical activity, and sometimes even include recognized medical functions (such as the FDA-approved atrial fibrillation detection of the Apple Watch). However, no device of this type allows for real-time quantification of molecules circulating in our blood or other bodily fluids, through optical methods. And that's exactly the challenge that Leo and his team at Spiden have set for themselves: to create the most advanced wearable, capable of continuously and non-invasively measuring multiple biomarkers circulating in our bodies. This could redefine our understanding of our own physiology and change our approach to medicine, by providing insights for the prevention, diagnosis, and monitoring of several conditions, that were previously inaccessible. Since its creation in 2017, Spiden has been operating away from the spotlight, but Leo does us the honor in this exclusive episode to reveal the first secrets behind Spiden’s technology. We discuss its functioning, its initial applications, who the future users will be, and also the incredible team of world-renowned scientists Leo has managed to bring together in the fields of optics, electronic engineering, and machine learning (three fields that were originally completely foreign to him) to achieve his vision. A fascinating conversation about the future of personalized medicine with a bold and successful entrepreneur! Timeline: 03:43 - Leo’s background as a serial entrepreneur from fintech to deep tech 04:56 - Why Leo found Spiden and works towards improving our health 07:14 - The mission of Spiden 11:00 - The technology behind Spiden 14:47 - The biomarkers that Spiden can track 19:02 - Target users of Spiden’s future wearable 22:28 - Designing a health-dedicated device 24:10 - Attracting world talents in fields you are not initially from 34:01 - The importance of in-person interactions in a scientific and multidisciplinary team What we also talked about with Leo: Continuous glucose monitoring (Abbott Freestyle Libre) Bits & Pretzels HealthTech Photoplethysmography (PPG) Biohacking Glucose Goddess Whoop Oura Garmin Huberman Lab induced pluripotent stem cells (iPSCs) We cited with Leo some of the past episodes from the series: #4 - Filtering the blood with nanoengineered beads - Lukas Langenegger - Hemotune #11 - Turning the lab into a wearable platform - Esmeralda Megally - Xsensio #21 - Transforming hypertension care with a bracelet - Jay Shah - Aktiia You can learn more about Spiden through their website. Feel free to follow as well their activities on LinkedIn! As mentioned by Leo during the episode, you can learn about the painful history of non-invasive glucose measurement through the book “The Pursuit of Noninvasive Glucose - Hunting the Deceitful Turkey” by John L. Smith. If you want to get in touch with Leo, feel free to contact him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, you can contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and kept up to date on the latest medical tech progress, simply subscribe here! And don’t forget to follow our activities on LinkedIn and our website!
49:08 04/09/2023
[EXTRACT] - Leo Grünstein on the future of smart wearables
To discover the whole episode type "#23 - Disrupting the smart wearables industry - Leo Grünstein - Spiden" on your streaming platform.
04:46 04/09/2023
#22 - Harnessing self-driving technology to guide the visually impaired - Maël Fabien - Biped.ai
Given the rapid progress made in this field in recent years, autonomous vehicles could soon become part of our daily lives, bringing with them all the consequences and questions they raise in terms of modern mobility. This would benefit people with visual impairments who are unable to drive. However, it wouldn't necessarily assist them in their pedestrian moves, which will always play a significant role in their daily lives. Maël Fabien became aware of the lack of available solutions in this regard during a walk in town. He noticed a visually impaired person video calling a friend, who was guiding her through his voice based on the video she was sharing. As a result, he took inspiration from the latest advances in autonomous vehicles to create a harness capable of continuously analyzing the pedestrian environment, and safely guiding its users in all their movements. From there, Biped was born, a device that promises to improve the life of the 270 million visually impaired people worldwide, by providing them with a much more accurate and secure perception of their environment than traditional solutions. In this surprising episode, you will learn about: The daily life of a visually impaired person and its impact on mobility How Biped was developed in close collaboration with its end users Some key concepts of autonomous mobility and the sensors that constitute it How Biped translates the user's 3D environment into audio cues for guidance The potential applications of Biped beyond ophthalmology An outlook on the future of mobility and what it might change for those with limited vision! Timeline: 02:01 - Maël’s interests at the interface of economics and speech processing 04:07 - Addressing the need for 270 million visually impaired 07:50 - What Biped is about 15:32 - How Biped reads and translates the environment of the user 22:30 - How users are trained on the system 24:14 - The spectrum of visually impaired people that Biped serves 30:08 - The underlying business model 32:19 - Potential applications beyond ophthalmology 34:58 - What users say about it 39:09 - Maël’s definition of impact What we talked also talked about with Maël: Idiap Research Institute Mobility training Lidar Bone conduction headphones Jules Gonin Eye Hospital Glaucoma Retinitis Pigmentosa Macular Degeneration Cochlear Implants You can learn more about Biped.ai through their website. Feel free to follow as well their activities on LinkedIn! As mentioned by Maël during the episode, you can find out more about the latest advances in autonomous driving and related AI through Tesla’s yearly AI Day (2022 recording here). He also recommends The Blind Life YouTube channel to understand how it feels to be in the shoes of a visually impaired person. If you want to learn more about Maël and his other endeavors besides Biped.ai, have a look at his blog! If you want to get in touch with Maël, feel free to contact him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, you can contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 And don’t forget to follow our activities on LinkedIn and through our website!
49:49 15/08/2023
[EXTRACT] - Maël Fabien on the notion of impact and building things that matter
To discover the whole episode type "#22 - Harnessing self-driving technology to guide the visually impaired - Maël Fabien - Biped.ai" on your streaming platform.
04:02 15/08/2023
#21 - Transforming hypertension care with a bracelet - Jay Shah - Aktiia
Few companies can claim to be a step ahead of tech giants in the wearable race. The Swiss company Aktiia can. They were the first to successfully bring to market a device capable of continuously and accurately measuring blood pressure, officially approved in Europe and soon to be in the US. All in a discreet bracelet that resembles a traditional jewel. It changes the game for how we approach hypertension, the first chronic condition worldwide affecting a staggering 1.4 billion people, and which comes with dire long-term consequences like strokes and heart attacks. The impact such groundbreaking technology can have on the daily lives of those affected is immense, not to mention its benefits for those in charge of their medical care. Say goodbye to the uncomfortable and cumbersome inflatable cuff (the actual “gold standard” to measure blood pressure), not to mention the major step forward in terms of design! Aktiia has defied expectations by merging optical and machine learning expertise over nearly two decades of cutting-edge research, resulting in a significant breakthrough in the world of wearables. In this new episode of the series, we sit with Jay Shah - the leading cardiologist and current Chief Medical Officer at Aktiia - who shares with us the story and functioning behind this stunning piece of technology. You will learn about: Hypertension and the public health crisis it represents The benefits of continuous blood pressure measurement How the Aktiia bracelet works How a small company like Aktiia was able to stand up to the biggest tech companies Preventive medicine and why empowering patients in their self-care matters A fascinating episode exploring the medical potential of wearables in our lives! Timeline: 02:30 - Jay’s background as a cardiologist and what led him to Aktiia 05:30 - The most common cause of cardiovascular diseases: hypertension 10:15 - What Aktiia is about and what it changes for blood pressure monitoring 15:50 - How Aktiia’s technology work 20:12 - The limits of the pattern-matching approach with wearable data 24:00 - Why Aktiia succeeded where big tech companies failed 27:45 - Who can get access to Aktiia’s bracelet 30:35 - How Aktiia empowers patients to take better control of their condition What we also talked about with Jay: Mattia Bertschi Josep Sola Massachusetts General Hospital Mayo Clinic Blood pressure cuff (sphygmomanometer) Photoplethysmography NextMed Health We cited with Jay some of the past episodes from the series: #1 - Measuring your arterial age to prevent heart diseases - Ted Baldwin - Imageens #12 - Unleashing the power of digital health - Daniel Kraft - Digital.Health You can learn more about Aktiia through their website. Feel free to follow their activities on LinkedIn, Twitter, and Instagram! As mentioned by Jay during the episode, you can find out more about the clinical research in hypertension and all the evidence developed around the bracelet in that regard here. For a very technical deep dive into cuffless blood pressure monitoring, we invite you to consult “The Handbook of Cuffless Blood Pressure Monitoring: A Practical Guide for Clinicians, Researchers, and Engineers” by Josep Sola himself, one of the founders from Aktiia. If you want to get in touch with Jay, feel free to contact him over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, you can contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 And don’t forget to follow our activities on LinkedIn and through our website!
51:40 01/08/2023
[EXTRACT] - Jay Shah on how wearables are changing healthcare
To discover the whole episode type "#21 - Transforming hypertension care with a bracelet - Jay Shah - Aktiia" on your streaming platform.
04:05 01/08/2023
#20 - Restoring touch through nerve repair - Karen Zaderej - Axogen
Restoring one of our five senses, in this case, touch. The stakes are immense (1 in 1000 people are affected yearly by a peripheral nerve injury!) and the origins are diverse: traumatic accident, cancer, amputation, and many others. And solutions to this problem have long needed to be improved. Karen Zaderej and her team at Axogen have set themselves the goal of changing this situation, by proposing new ways of treating nerves, taking advantage of their regenerative potential. A chemical engineer by training, Karen began her career at Johnson & Johnson in its surgical solutions subsidiary, ETHICON. With 17 years of experience in roles ranging from manufacturing to product development and sales, she decided to leave her corporate career behind. In 2006 she joined a Floridian start-up in its infancy, developing a new type of medical device enabling nerves to regenerate, still at the prototype stage and not yet tested on humans. The outcome? A company that has become a world leader in the development of cutting-edge nerve repair solutions, listed on the stock exchange and now employs over 400 people. In this new episode, we delve into the world of peripheral nerves, the source of our physical and motor sensations, and their formidable regenerative capacities. You will learn about: How our nerves work and current approaches to repairing them Phantom pain, how to explain it, and how to treat it How women today can regain sensation in their breasts following a mastectomy The journey of a remarkable woman entrepreneur who has made addressing nerve damage her life mission Prepare to be nervously amazed as we unravel the secrets of touch restoration! Timeline: 00:03:00 - Karen’s background as a nerve evangelist 00:07:35 - Key evolutions in medical technology that Karen witnessed 00:10:42 - What Karen learned at J&J that shaped the rest of her career 00:15:43 - What attracted Karen to Axogen and the potential of their technology 00:20:40 - Scaling up a medical device company from a very early stage onwards 00:23:15 - How Axogen enables nerve repair 00:27:18 - Bringing an answer to phantom pain 00:30:47 - The main indication areas covered by Axogen 00:38:31 - What the future of nerve repair might look like What we also talked about with Karen: Autograft Allograft Mastectomy Neuroma Da Vinci Surgical Systems We cited with Karen some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore #2 - Treating liver cancer with surgical robotics - Lucien Blondel - Quantum Surgical You can learn more about Axogen through their website and their portfolio here. Feel free to follow as well their activities on LinkedIn, Twitter, and Facebook! As mentioned by Karen during the episode, you can find out more about clinical research in peripheral nerve repair through the complete library of published papers curated by the company. Karen also invites you to consult resensation.com and rethinkpain.com to hear about patient stories and find resources in case you face a similar situation. If you want to get in touch with Karen, feel free to contact her over LinkedIn. If you want to give me feedback on the episode or suggest potential guests, feel free to do so contact me over LinkedIn or via email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! Follow also our activities on LinkedIn and through our website!
52:25 26/06/2023
[EXTRACT] - Karen Zaderej on the resensation technique for women having gone through mastectomy
To discover the whole episode type "#20 - Restoring touch through nerve repair - Karen Zaderej - Axogen" on your streaming platform.
04:03 25/06/2023
#19 - Saving lives through cybersecurity - Richard Staynings - Cylera
We all know that medical data is sensitive personal information, which we would not like to have falling into the wrong hands. Along with the progress of digitalisation in healthcare, the number of cyberattacks towards this particular sector has dramatically increased over the past years. The ultimate risk? Slowed or even paralysed hospitals, with lives lost as a consequence. Since all of this happens in the background, it’s hard to grasp the severity of the situation, and the majority of us are not equipped with the expertise to understand how those events actually unfold. With decades of experience as a healthcare Chief Information Security Officer and current Chief Security Strategist at Cylera, Richard Staynings has seen firsthand the devastating consequences of such attacks on patients, providers, and organizations. But he's also a firm believer that with the right strategies, tools, and mindset, we can win the war against cyber threats in healthcare. In this episode, we dive headfirst into the high-stakes world of healthcare cybersecurity with one of the industry's most respected voices. You will learn about: The risks cyberattacks carry for health systems The most common types of cyberattacks in this sector The entities behind those threats What health systems can do to ensure their safety A conversation packed with eye-opening perspectives and actionable advice for anyone working in healthcare or concerned about its future! Timeline: 02:14 - introduction on Richard’s background and the mission of Cylera 03:26 - why cybersecurity matters in healthcare 07:58 - the example of WannaCry in the UK 10:46 - the main sources of threat for healthcare systems 29:46 - the approach Cylera takes to safeguard its clients What we also talked about with Richard: General Keith Alexander Malware Ransomware Denial-of-service attack Zero-day exploits The Interview The CIA Triad As mentioned in the episode, you can learn more about Cylera through their website and their approach here. You can also follow their activities on LinkedIn or Twitter! For further information about cybersecurity in healthcare, we’d recommend the Blog section from Cylera and the website curated by Richard himself: cyberthoughts.org. If you want to get in touch with Richard, feel free to contact him per email at richard.staynings@cylera.com, on LinkedIn or Twitter. In case you want to give me feedback on the episode or the podcast in general, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com! If you liked the episode, please share it, subscribe to the podcast and leave a 5-star review on streaming platforms! We also invite you to follow our activities through our website, LinkedIn and Instagram!
55:54 26/04/2023
[EXTRACT] - Richard Staynings on the consequences of cyberattacks in healthcare
To discover the whole episode type "#19 - Saving lives through cybersecurity - Richard Staynings - Cylera" on your streaming platform.
03:49 26/04/2023
#18 - The dark genome as the next revolution in drug discovery - Samir Ounzain - HAYA Therapeutics
Most of our genome does not code for any protein, which led us to believe that 98% of our genetic material was useless. But what was initially termed as the “dark side of the genome” (which Star Wars fans will certainly appreciate!) turns out to play a crucial role in modulating our biology. It is in fact the software translating environmental factors (e.g. air quality, lifestyle, stress, etc.) into biological mechanisms, which can either lead to the proper functioning of our body or to certain illnesses. The stakes and the potential around its use to develop new treatments are therefore immense! And this is exactly what HAYA Therapeutics has been focusing on over the past few years: leveraging the science behind the “dark genome” to develop revolutionary treatments for chronic diseases, starting with heart failure. The promise compared to traditional approaches? More effective and targeted effects, focusing on one type of tissue only Lower therapy development costs due to shorter development processes So what stands behind this mysterious concept exactly? What is the science behind it? And how can this drive the development of new therapies to address some of the most widespread conditions across the globe? In this new episode of Impulse, learn all about this fascinating field in the words of Samir Ounzain - CEO from HAYA Therapeutics - on a mission to radically change the way we approach drug discovery and development. Passionate and didactic, he unveils the secrets of the “dark genome”, the influence of our surrounding environment on our genetics, and how we could leverage our understanding of this field to treat chronic diseases in a new way! Timeline: 02:32 - Samir’s background and how he got passionate about genetics 08:30 - What the “dark genome” is actually about 11:38 - How our understanding of the “dark genome” sparked the idea of what will become HAYA Therapeutics 25:30 - How HAYA Therapeutics aims to address heart failure 32:47 - Longevity and other applications on the long run 36:42 - How such new treatment would be delivered What we also talked about with Samir: Jurassic Park Wisper long noncoding RNA RNA interference & Anti-Sense Oligonucleotides Renin-angiotensin system We cited with Samir some of the past episodes from the series: #1 - Measuring your arterial age to prevent heart diseases - Ted Baldwin - Imageens As mentioned in the episode, you can learn more about HAYA Therapeutics through their website and their approach here. You can also follow their activities on LinkedIn or Twitter! For further information about the dark side of the genome and the science behind it, we’d recommend you to check out the book from John Mattick and Paulo Amaral entitled “RNA the Epicenter of Genetic Information”, as well as the interview of Manolis Kelis on Lex Fridman Podcast. A recent article by the BBC featuring Samir also details out what the dark genome is about and goes quite deep into the topic, worth checking out as well! If you want to get in touch with Samir, feel free to contact him per email at samir@hayatx.com, on LinkedIn or Twitter. In case you want to give me feedback on the episode or the podcast in general, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com. If you liked the episode, please share it, subscribe to the podcast and leave a 5-star review on streaming platforms! We also invite you to follow our activities through our website, LinkedIn and Instagram pages!
53:34 14/04/2023
[EXTRACT] - Samir Ounzain on the dark genome and its importance in human biology
To discover the whole episode type "#18 - The dark genome as the next revolution in drug discovery - Samir Ounzain - HAYA Therapeutics" on your streaming platform.
03:53 14/04/2023
#17 - Coaching as the key to a better health - Eugene Borukhovich - YourCoach.Health
How can we support each and every one of us in identifying and pursuing our goals towards a healthier life, in a world where access to care seems to be continuously shrinking? The solution may lie in health coaching and making it accessible across the globe. Having witnessed his wife successfully battling breast cancer and becoming a certified health coach, Eugene Borukhovich joined her entrepreneurial adventure at YourCoach.Health in 2020 to co-found the first and only operating system for behavior change powered by an army of helath and wellness coaches. As a recognized and beloved leader in the healthcare space, Eugene relies on his incredibly diverse experience in the space - as an intra- and entrepreneur, executive, venture builder, advisor and even podcaster - to drive the operations of the platform. Three years down the line, it regroups more than 3000 certified health coaches, impacting a number of lives higher by several orders of magnitude, on a daily basis. There is still a long way to go to reach the projected 9 billion people on earth by 2030, but their determination is unquestionable: join the journey and learn all about health coaching in this new episode, the science behind it, and what it can do for you! Timeline: 02:22 - Eugene’s background in healthcare and most particularly digital health 07:35 - What triggered Eugene’s move towards entrepreneurship and health coaching 11:19 - What health coaching is about 20:41 - Moving from a Global corporate role to being your own boss 24:54 - Eugene’s take on making collaborations between startups and corporates in healthcare successful 29:23 - What led Eugene to go into podcasting and start the DTx Podcast and Shot of Digital Health Therapy What we also talked about with Eugene: Meetup Scott Heiferman Matthew Holt Indu Subaiya Health 2.0 Conference Lark Health Twill Marina Borukhovich Bayer G4A Hard Pill To Swallow Dan Kendall Jim Joyce As mentioned in the episode, you can learn more about YourCoach.Health through their website and their app available on the App Store or Google Play Store. You can also follow their activities on LinkedIn, Instagram, Twitter and Facebook! For further information about health coaching and the science behind it, we’d recommend you to check out the podcast produced by the YourCoach.Health team, as well as The National Board for Health and Wellness Coaching. If you want to get in touch with Eugene, feel free to contact him per email at eugene@yourcoachhealth.com, or on LinkedIn, Twitter and Instagram. In case you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com. If you liked the episode, share it, subscribe to the podcast and leave a 5-star review on streaming platforms! We also invite you to follow our activities through our website, LinkedIn, Twitter and Instagram pages.
43:08 21/02/2023
[EXTRACT] - Eugene Borukhovich on health coaching and the importance of human-to-human interactions
To discover the whole episode type "#17 - Coaching as the key to a better health - Eugene Borukhovich - YourCoach.Health" on your streaming platform.
03:55 21/02/2023
#16 - Making ultrasound portable to transform medical imaging - Ohad Arazi - Clarius
Starting a career in the Israeli army, becoming a lawyer, and finally transforming the field of medical imaging. In a very schematic way, this is what might define Ohad Arazi’s path, who is now spearheading the field of handheld ultrasound as the CEO of Clarius. His curiosity for medical imaging - coupled with a very product-oriented mindset and an unrelenting desire to understand the problems that healthcare faces - leads him to integrate different structures, including the Fortune 500 giant McKesson, the Canadian telecommunication company Telus, and the Israeli startup Zebra Medical Vision, where he quickly occupies leadership roles with great responsibility. At Clarius (this “true gem” as he calls it in his own words) he draws on his expertise in the field of medical imaging to embed artificial intelligence into the most compact high quality ultrasound imaging platform on the market, developed by its brilliant founder Laurent Pelissier. The goal? Allowing any healthcare professional to perform an ultrasound scan, with a system as intuitive, qualitative, and compact as an iPhone. Perhaps those will even find their place in patient’s homes at some point! In light of the current boom in digital health and the radical developments in AI, Ohad shares his perspective on the role that these technologies will have on certain medical specialities and notably radiology, where he believes that they will rather augment them without replacing them. He also explains why he thinks that most technological capabilities in digital health are outstripping the value they can create, and reflects on his career path where his transitions from huge corporates to human-sized startups shaped his evolution and leadership. A surprising dive into the future of medical imaging, that we invite you to discover in this new episode! Timeline: 02:23 - Ohad’s background, from the military in Israel to healthcare in Canada 10:46 - What the medical imaging landscape looked like in the early 2000s 14:51 - Ohad’s take on the current boom in digital health 19:36 - Clarius’ mission in transforming high-end ultrasound for healthcare professionals 33:11 - How AI is embedded into the products from Clarius 35:09 - Dealing with hypergrowth as a medical imaging startup 39:48 - Ohad’s reflections on his career path and the story of the Disney brothers What we also talked about with Ohad: OpenAI Turtle Health US2.ai PACS DICOM EHR James Hare Carolyn Lam We cited with Ohad some of the past episodes from the series: #1 - Measuring your arterial age to prevent heart diseases - Ted Baldwin - Imageens #12 - Unleashing the power of digital health - Daniel Kraft - Digital.Health As mentioned in the episode, you can learn more about Clarius through their website and follow their activities on LinkedIn, Twitter, Facebook, Instagram and YouTube! If you want to get in touch with Ohad, feel free to contact him per email at ohad.arazi@clarius.com or through LinkedIn. If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com. And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! Finally, you can follow our activities through our website, over LinkedIn, Twitter or on Instagram!
50:20 09/02/2023
[EXTRACT] - Ohad Arazi on the importance of understanding the problem you are trying to solve
To discover the whole episode type "#16 - Making ultrasound portable to transform medical imaging - Ohad Arazi - Clarius" on your streaming platform.
02:38 09/02/2023
#15 - Propelling diagnostics through miniaturization - Nicolas Durand - Abionic
Nicolas Durand is the CEO of Abionic, a Swiss-based startup which developed and commercialises the abioSCOPE®, a unique diagnostic platform characterised by its compact size and ability to deliver high quality results in a fraction of time. Passionate about high tech and wishing to become an entrepreneur from a very early age (he created his first company with a friend at school when he was 14 years old) he turned his PhD work into a venture, which today represents one of the most successful medtech startups in the country! We discuss with Nicolas the nanotechnology behind Abionic, the types of tests it can run, the targeted diseases, the efforts it takes to demonstrate the clinical efficacy of a new diagnostic device, but also the energy required to convince all the actors involved in the care pathway, from regulators, doctors, to patients. He also shares openly about his vision regarding the potential emergence of home diagnostic systems in the future, as well as his perspective on the impact that the Theranos scandal had on the diagnostics industry, and in particular on startups operating in this field. A conversation under the sign of resilience and excellence that we invite you to discover in this new episode! Timeline: 02:05 - Nicolas’ background and his original interest in high technology and entrepreneurship 04:07 - Creating your first company at 14 years old 06:54 - What Abionic is about and how its core diagnostic technology works 21:45 - Miniaturizing diagnostic tests beyond immunoassays 25:07 - The clinical settings where the abioSCOPE® is placed 27:25 - Towards the use of diagnostic systems at home 32:15 - The impact of the Theranos scandal on medtech startups What we also talked about with Nicolas: Philippe Renaud Robopoly PSP Sepsis IVDR Elizabeth Holmes Red Bull Air Race We cited with Nicolas some of the past episodes from the series: #4 - Fighting sepsis with nanoengineered beads to filter the blood - Lukas Langenegger - Hemotune #5 - Transforming diagnostics through spatial biology - Déborah Heintze - Lunaphore #12 - Unleashing the power of digital health - Daniel Kraft - Digital.Health #13 - Catalyzing drug discovery using organ-on-a-chip models - Bas Trietsch - Mimetas As mentioned in the episode, you can learn more about Abionic through their website and follow their activities on LinkedIn, Twitter and Facebook! Based on Nicolas’ suggestion, we invite you to read Bad Blood: Secrets and Lies in a Silicon Valley Startup by John Carreyrou to learn more about Elizabeth Holmes and the scandal around Theranos which literally shook the whole medtech industry in the past years! If you want to get in touch with Nicolas, feel free to contact him per email at nicolas.durand@abionic.com or through LinkedIn. If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com. And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! Finally, you can follow our activities through our website, over LinkedIn, Twitter or on Instagram!
44:10 18/01/2023
[EXTRACT] - Nicolas Durand on Theranos and how it could have been a success
To discover the whole episode type "#15 - Propelling diagnostics through miniaturization - Nicolas Durand - Abionic" on your streaming platform.
03:36 18/01/2023
#14 - Preserving our health with smart clothes - Vincent Martinez - Nanoleq
Will the next revolution in personalized health be led by connected clothes? This is the bet that Vincent Martinez and his team at Nanoleq are making, and they are putting all their efforts into turning their vision into reality! Originally, their idea was to target the cable industry with a proprietary technology enabling to create stretchable cables, with superior physical and electrical properties. The targeted companies being too slow in their adoption of the proposed approach, Vincent and his team decide to tackle the field of connected clothing, by proposing a set of components and tools enabling any clothing manufacturer to turn their garments into smart ones, able to measure multiple vital parameters but also to electrically stimulate certain regions of the body. Building upon their expertise in this space, they developed the first breathing smart garment with live biofeedback - Oxa - around which they designed a whole personalized program for everyone to reconnect to their body through breathing, the only vital sign we can consciously control. We talked with Vincent about the emergence of connected clothes and what role they will play in the preservation of our health, how stretchable electronics work, and how Nanoleq managed to develop a full breathing experience combining cutting-edge sensors with gamification, backed by the most renown ambassadors in the field. Timeline: 00:58 - Vincent’s background at the interface of materials science and biomedical engineering 02:57 - Launching a company to address the premature breakage of electronic cables 07:45 - What lies behind the term « stretchable electronics » 09:55 - Shifting the focus towards smart textiles 19:48 - The vision of Nanoleq around connected health 24:05 - Starting a new product line focused on breathing optimization: Oxa Life 35:00 - Federating a community of breathing specialists 37:46 - Making the most personalised and digitally engaging breathing optimization program 44:14 - Towards everyday wear of smart clothes What we also talked about with Vincent: ETH Pioneer Fellowships Luca Hirt Grégoire Courtine Start Summit Venture Kick Venture Electrical Muscle Stimulation (EMS) Wim Hof Sleep apnea Dan Brulé Headspace Petit Bambou Andrew Huberman We cited with Vincent some of the past episodes from the series: #6 - Bringing back walking to paraplegics - Jocelyne Bloch - .NeuroRestore #11 - Turning the lab into a wearable platform - Esmeralda Megally - Xsensio As mentioned in the episode, you can learn more about Nanoleq and the field of stretchable electronics through their website. The Kickstarter campaign for Oxa runs until Sunday December 18 and you can contribute to it at this page! For more information about Oxa, check out the official product page: www.oxalife.com. Based on Vincent’s suggestions, check out the book Breath from James Nestor or this episode of Huberman Lab if you want to know more about the science behind breathing and the exercises that we discussed in this episode. You can also learn more about the Buteyko method here. If you want to get in touch with Vincent, feel free to contact him per email at martinez@nanoleq.com or through LinkedIn. If you want to give me feedback on the episode, ask questions or suggest potential guests, feel free to do so through LinkedIn or per email at mathieu@impulsepodcast.com. And if you liked the episode, don’t hesitate to share it, subscribe to the podcast and leave a positive review on streaming platforms! Finally, you can follow our activities through our website, over LinkedIn, Twitter or on Instagram!
56:12 14/12/2022
[EXTRACT] - Vincent Martinez on the rise of smart textiles and their relevance in personalized health
To discover the whole episode type "#14 - Preserving our health with smart clothes - Vincent Martinez - Nanoleq" on your streaming platform.
03:59 14/12/2022

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