Show cover of American Journal of Psychiatry Audio

American Journal of Psychiatry Audio

Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research. This podcast is subject to the Terms of Use at ww.psychiatry.org. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.

Tracks

May 2024: Predictors of Substance Use Initiation by Early Adolescence
Dr. ReJoyce Green (Medical University of South Carolina, Charleston, SC) joins AJP Audio to discuss predictors of substance use initiation in a large cohort of early adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin speaks with AJP Deputy Editor Dr. Kathleen Brady about the May issue of AJP, a special issue guest edited by Dr. Brady focusing on latest developments in the understanding and treatment of substance use disorders. Transcript 00:48     Green interview 03:04     Why is it important to study substance use initiation? 04:06     Social and family-related factors versus imaging and neurocognitive factors 05:58     Age and cohort concerns 07:15     Religious participation as a predictive factor 09:04     Clinical implications 11:03     Limitations 12:24     What’s next for your research? 13:36     Kalin and Brady interview 17:09     Green et al. 19:52     Morley et al. 23:34     Radoman et al. 26:21     Hoffman et al. 29:00     Blalock et al. Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
36:45 5/6/24
April 2024: Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability
Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability. 00:56     Hwang interview 02:09     Effects of oxytocin 05:45     Intranasal oxytocin 07:04     Potential adverse effects of oxytocin 08:08     Imaging 08:58     Preliminary investigations and clinical implications 09:51     Limitations 10:14     Further research 11:00     Kalin interview 11:33     Hwang et al. 14:43     Leibenluft et al. 15:39     Aggarwal et al. 18:22     Pezzoli et al. 21:34     Kendler et al. 23:30     Hou et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
27:39 4/1/24
March 2024: Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial
Dr. Drew Rothenberg (Duke University, Durham, NC) joins AJP Audio to discuss the long term, intergenerational impacts of the Fast Track program, and whether the mental health intervention lead to lasting improvements in mental health, including in the participants own children.   00:49     Rothenberg interview 04:36     A null result? 07:13     At risk children from high risk neighborhoods 08:00     Limitations 09:17     Demand for childhood mental health services and clinical implications 11:10     Further research 13:59     Kalin interview 14:12     Rothenberg et al. 16:12     Haller et al. 18:49     Poirot et al. 20:55     Ainsworth et al. 23:20     Rosenqvist et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
27:55 3/1/24
February 2024: Trends in Prevalence of Cannabis Use Disorder Among U.S. Veterans With and Without Psychiatric Disorders Between 2005 and 2019
Dr. Ofir Livne (Columbia University, New York) joins AJP Audio to discuss recent trends in the prevalence of cannabis use disorder in US veterans with and without psychiatric disorder diagnosis.  Dr. Ned Kalin joins afterwards to discuss how the rest of the February issue of AJP touches on cannabis use disorder and other substance use disorders. 00:31     Livne interview 03:16     Changes in the legal landscape surrounding cannabis use 05:17     The complex association between cannabis use and psychiatric disorders 07:20     Clinical implications 08:02     Limitations 09:44     Future directions for research 10:13     Kalin interview 10:30     Livne et al. 12:30     Gustafson et al. 14:44     Garland et al. 16:10     Wilson et al. 18:06     Huang et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
21:56 2/1/24
January 2024: Predicting Acute Changes in Suicidal Ideation and Planning: A Longitudinal Study of Symptom Mediators and the Role of the Menstrual Cycle in Female Psychiatric Outpatients With Suicidali
Dr. Jaclyn Ross, Ms. Jordan Barone, and Dr. Tory Eisenlohr-Moul (University of Illinois at Chicago) join AJP Audio to discuss the impact of the menstrual cycle on suicide ideation and planning in psychiatric patients with suicidality. Afterwards, American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin brings us up to date on the rest of the January issue of AJP. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
35:26 1/1/24
December 2023: Racial and Ethnic Disparities in COVID-19-Related Stressor Exposure and Adverse Mental Health Outcomes Among Health Care Workers
Dr. Aaron Samuel Breslow (Montefiore Medical Center and Albert Einstein College of Medicine) joins AJP Audio to discuss the racial and ethnic disparities in the impact of COVID-19 and pandemic related stressors and adverse mental health outcomes on health care workers in the Bronx, New York.  Following we’ll once again check in with American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin on the rest of the December issue of AJP. Breslow interview [00:56] Why look at the Bronx in particular? [2:54] COVID-19 related stressors and pandemic related stressors [05:27] Unrelated adverse mental health outcomes [07:40] Limitations [09:29] Policy considerations [11:39] Further research [14:22] Kalin interview [16:17] Breslow et al. [16:34] Guintivano et al. [18:36] Copeland et al. [22:10] Joseph et al. [25:21] Shim and Rodriguez [27:15] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
28:01 12/1/23
November 2023: Inequalities in the Incidence of Psychotic Disorders Among Racial and Ethnic Groups
Dr. Winston Chung (Kaiser Permanente Northern California) joins AJP Audio to discuss inequalities in the diagnosis of psychotic disorders between racial and ethnic groups in a large cohort. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the November issue of AJP, which focuses on different aspects of psychotic disorder. Chung interview [00:30] Structural racism and missing socioeconomic strata [02:58] Effective and non-effective psychosis [04:20] Limitations [05:48] Differential rates of treatment and non-treatment [06:58] Policy implications [07:40] Further research [08:31] Kalin interview [08:58] Chung et al. [09:14] Rødevand et al. [11:27] Cao et al. [14:07] Smucny et al. [16:18] Cannon [17:03] Transcript   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
19:53 11/1/23
October 2023: Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two U.K. Cohorts
Dr. Luis Farhat and Dr. Guilherme V. Polanczyk (University of São Paulo, Brazil) join AJP Audio to discuss the impact of socioenviromental factors, emotional dysregulation, and other factors impact neurodevelopment in children. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Farhat and Polanczyk interview [00:54] Comorbidities and associations [03:22] Twins Early Development Study and the Avon Longitudinal Study of Parents and Children [04:47] Limitations [07:35] Clinical Implications [09:32] Further research [11:48] Kalin interview [13:20] Farhat et al. [13:35] Nguyen et al. [15:37] Docherty et al. [18:02] Chatzinakos et al. [20:18] Marr et al. [24:06] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
28:52 10/1/23
September 2023: Disparities in Suicide-Related Behaviors Across Sexual Orientations by Gender: A Retrospective Cohort Study Using Linked Health Administrative Data
Dr. Antony Chum (York University, Toronto) joins AJP Audio to discuss disparities in suicide-related behaviors between sexual orientations by gender in a large cohort from the province of Ontario. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Transcript Chum interview [00:34] Results [02:14] Using a large data set [03:21] Correcting the limitations of previous research [04:40] Taking changing societal circumstances into account [06:11] Immediate clinical implications [07:57] What’s next for your research? [09:47] Kalin interview [11:23] Chum et al. [11:34] Widge et al. [13:15] Russell et al. [15:06] Deligiannidis et al. [15:34] Clayton et al. [18:41] Kumar et al. [19:59] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
24:19 9/1/23
August 2023: A Comprehensive Multilevel Analysis of the Bucharest Early Intervention Project: Causal Effects on Recovery From Early Severe Deprivation
Dr. Lucy S. King (Tulane University School of Medicine, New Orleans) and Dr. Kathryn L. Humphreys (Vanderbilt University, Nashville) join AJP Audio to discuss the long term impacts of a pioneering randomized controlled trial that looked at the impacts of institutional care versus home foster care in children, the Bucharest Early Intervention Project.  They also discuss the impacts of deprivation on children’s development and mental health, and the thorny ethics of research involving children. Transcript The impact of deprivation [01:19] Bucharest Early Intervention Project and the ethics of research involving children [04:43] Analyzing diverse data [08:57] Why revisit this trial? [16:05] Long term impacts of the intervention [18:39] Limitations [23:22] Policy implications [26:16] Further research [30:18]  Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  
32:44 8/1/23
July 2023: Differences in Social Determinants of Health Underlie Racial/Ethnic Disparities in Psychological Health and Well-Being: Study of 11,143 Older Adults
Dr. Dylan J. Jester (VA Palo Alto Medical Center in Palo Alto, California) joins AJP Audio to discuss the differential impact of selected social determinants of health on the mental health outcomes of older Black, White, and Latinx adults in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the July issue. Transcript Jester interview [00:48] Which social determinants of health did you focus on? [03:31] Societal factors versus individual criteria [04:30] Data [05:25] Lessons for policymakers [06:30] Limitations [07:37] What’s next for your research? [08:36] Kalin interview [10:11] Jester et al. [10:21] Dienel et al. [12:50] Jacob et al. [16:15] Joshi et al. [18:50] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  
22:18 7/1/23
June 2023: Opioid Prescribing and Suicide Risk in the United States
Dr. Mark Olfson (Columbia University) discusses the links between opioid prescribing and suicide risk in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the June issue. Transcript Olfson interview [00:46] Geographic commuting areas [01:06] Opioid prescription measures [02:10] Rates of opioid prescription and suicide [03:27] Youngest age cohorts as outliers [04:19] Regional variations [04:57] Limitations [05:17] Clinical implications [05:55] What’s next for your research? [06:21] Kalin interview [06:42] Olfson et al. [07:00] Vickers-Smith et al. [08:36] Rognli et al. [10:44] Garrison et al. [12:51] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
16:19 6/1/23
May 2023: Attention Bias Modification Treatment Versus a Selective Serotonin Reuptake Inhibitor Or Waiting List Control for Social Anxiety Disorder
Ms. Gal Arad (Tel Aviv University, Tel Aviv, Israel) discusses a non-pharmacological intervention for the treatment of social anxiety disorder in comparison with standard care.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the May issue. Transcript Arad interview [00:18] What were your results? [02:11] Reduction in dwell time on threatening faces [03:36] Limitations [04:09] Immediate clinical implications [05:27] Further research [05:58] Kalin interview [06:37] Arad et al. [06:55] Grant et al. [09:07] Reddy et al. [10:59] Taipal et al. [13:28] Buchanan and Krane [14:39] Brandt et al. [15:41] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
20:05 5/1/23
April 2023: Translational Neuroscience Approaches to Understanding Autism
Dr. David G. Amaral (University of California, Davis) is an author of a review paper in the April issue of AJP looking at the use of animal models and other forms of translational neuroscience in the investigation of autism spectrum disorder.  He joins us on AJP Audio to discuss it.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the April issue.  Transcript   Amaral interview [00:56] Advantages and disadvantages of animal model research [02:14] What goes into determining which animals might be good candidates for research in human neurology? [04:52] How does basic research get translated into clinical treatments? [08:28] Alternatives to animal models [10:21] Promise of research moving forward [12:22] Kalin interview [15:30] Veenstra-VanderWeele et al. [15:46] Kato et al. [17:02] Zwicker et al. [19:17] Kim et al. [22:22] Zeng et al. [26:14] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
29:55 4/3/23
March 2023: Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder
Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue. Transcript Sachs interview [00:47] Why is treating major depressive disorder in patients proven to be such a challenge for clinicians? [01:54] Why cariprazine in conjunction with antidepressants? [02:37] Atypical antipsychotics and antidepressants [03:22] Atypical antipsychotics and side effects [05:23] Limitations [07:09] Clinical implications for the treatment of major depressive disorder [08:29] What’s next for your research? [09:15] Kalin interview [10:09] Sachs et al. [10:25] Hasseris et al. [12:35] Visontay et al. [15:15] Dunlop et al. [17:10] Elbau et al. [19:56] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
24:25 3/1/23
February 2023: Adversity, Toxic Stress, and Racial Disparities in Children, and Evaluating the Evidence for Brain-Based Biotypes
This episode of AJP Audio features two articles from the February issue of AJP.  First up, we have Nathaniel G. Harnett, Ph.D. (Harvard Medical School), discussing the impact of adversity and stress on racial disparities in childhood brain development among Black and White American children.  Following that, Ziv Ben-Zion, Ph.D. (Yale University), discusses a non-exact replication study of a study published in AJP by Stevens et al. (previously featured on AJP Audio) looking at brain-based biotypes to guide treatment following trauma.  And of course, we’ll check in with AJP Editor-in-Chief Dr. Ned Kalin about the rest of the February issue and how it all fits together. Transcript Harnett interview [01:05] How do less tangible factors like trauma, stress, and exposure to violence impact brain development? [03:07] What do you mean by toxic stress? [04:41] Why did you choose to focus on those regions of the brain? [06:01] Regional variability and privacy concerns [07:50] Limitations [09:11] Future research [10:59] Children and the limited control of their environment [12:10] Ben-Zion interview [13:39] Challenges of running a non-exact replication study [15:12] Limitations [18:35] Should researchers consider replication in study design? [21:26] Future research [24:24] Kalin interview [27:46] Dumornay et al. [28:08] Baldwin et al. [30:02] Cleary et al. [31:38] Ben-Zion et al. [34:15] Hien et al. [37:08] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
39:47 2/1/23
January 2023: Resting-State Connectivity and Response to Psychotherapy Treatment in Adolescents and Adults With OCD: A Randomized Clinical Trial
Dr. Stefanie Russman Block (University of Michigan, Ann Arbor) discusses a trial looking at whether connectivity patterns in the brain can be used to predict treatment response in patients with obsessive-compulsive disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses childhood and neurodeveloment-related psychiatric disorders explored in the January issue. Russman Block interview [00:51] Exposure and response prevention versus stress management therapy [05:46] Investigating adolescents and adults [07:02] Clinical implications [08:29] Limitations [10:02] Further research [11:56] Kalin interview [12:57] Russman Block et al. [13:12] Webb et al. [14:57] Floris et al. [17:45] Shimelis et al. [21:27] Brikell et al. [26:04] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
30:51 1/3/23
December 2022: A Novel, Brief, Fully Automated Intervention to Extend the Antidepressant Effect of a Single Ketamine Infusion: A Randomized Clinical Trial
Dr. Rebecca Price (University of Pittsburgh) discusses a novel, computer-based intervention designed to extend the antidepressant effects of a single dose of ketamine. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue and what draws it together. Price interview [00:40] What does the computer-based intervention consist of? [03:55] Comparator arms [05:25] Are there immediate clinical implications? [08:04] Limitations [10:19] Further research [12:17] Kalin interview [14:02] Price et al. [14:28] Santos et al. [17:28] Grilo et al. [19:43] Solmi et al.v [22:51] Lam et al. [25:01] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
29:33 12/1/22
November 2022: Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy
Dr. Antonia Seligowski (McLean Hospital and Harvard Medical School) discusses how significant genetic correlations were identified between PTSD and cardiovascular disease as well as support for a causal link from PTSD to hypertension and coronary artery disease.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue and what draws it together. Seligowski interview [00:50] Genome-wide association studies [02:24] The Mass General Brigham Biobank [03:05] What were the limitations of the study? [04:05] Are there current clinical implications? [05:04] How does depression fit in? [06:11] Are the links between PTSD and cardiovascular disease linked to associated comorbidities? [07:00] What’s next for your research? [07:52] Kalin interview [08:51] Seligowski et al. [09:06] Leone et al. [10:57] Hindley et al. [13:50] Lewis and Vassos [17:37] Sigström et al. [18:13] Brownstein et al. [20:32] In summary [25:03] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  
26:13 11/1/22
October 2022: Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training
Dr. Richard Davidson (University of Wisconsin-Madison) discusses the effects of mindfulness training on the neural mechanisms of pain and what it means for the future of pain management. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses what draws together that paper and the rest of the October issue. Davidson interview [00:37] How do you go about investigating pain? [05:41] Lack of apparent difference in neural response among long-term meditators [06:45] What does this mean for pain management? [08:33] Limitations [09:46] Next steps for research [10:42] Kalin interview [11:50] Wieglosz et al. [12:01] Hasin et al. [14:25] Jutras-Aswad et al. [16:46] Lin et al. [19:08] Hasin et al. [20:36] In summary [22:34] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the October 2022 issue of AJP. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
25:46 10/3/22
September 2022: Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure
Dr. Lauren A. M. Lebois (Dissociative Disorders and Trauma Research Program, McLean Hospital, Harvard Medical School) discusses persistent dissociation following trauma exposure and whether it can be predictive of later psychiatric outcomes in at risk populations. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue and what draws it together. Lebois interview [00:52] A prototypical adult dissociation case [01:51] Dissociation as a rollercoaster [05:48] The many ways of dissociation can be activated [08:04] Investigation through self-reporting and imaging [08:55] The imaging cohort [11:16] Biomarkers associated with dissociation and later psychiatric outcomes [11:54] Clinical treatment implications [15:09] Cambridge Depersonalization Scale and the Multidimensional Inventory of Dissociation [16:22] Limitations [16:57] What’s next for your research? [18:01] Kalin interview [19:42] Lebois et al. [19:56] Gregersen et al. [22:33] Kendler et al. [24:58] Chand et al. [27:49] Jaffe et al. [31:45] In summary [34:39] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the September 2022 issue of AJP. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
36:30 9/1/22
August 2022: Subcortical Brain Development in Autism and Fragile X Syndrome
Dr. Mark D. Shen (University of North Carolina, Chapel Hill) discusses the trajectory of brain development in infants at risk for autism spectrum disorder (ASD) and fragile X syndrome.  Longitudinal imaging was captured from 6 to 24 months to see how brain development differed between groups, and the development of the amygdala in infants at risk for ASD prior to onset of social deficits and clinical diagnosis. Shen interview [01:03] Why look at patients with potential ASD diagnosis in conjunction with fragile X syndrome patients? [04:20] Why are differences in brain structure important? [05:46] What’s the advantage of earlier diagnosis of ASD? [08:16] What’s next for your research? [09:48] Kalin interview [11:47] Shen et al. [12:09] Girault et al. [15:30] Gerlach et al. [19:13] Mosholder et al. [22:12] Summary [25:31] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Transcript Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the August 2022 issue of AJP. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
27:47 7/29/22
July 2022: Digital Intervention for Cognitive Deficits in Major Depression
Dr. Richard S.E. Keefe (Duke University Medical Center, Durham, North Carolina) discusses an article looking at an intervention for major depressive disorder that takes the form of a videogame. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the July issue’s theme. Keefe interview: [01:00] What were your results? [03:13] What do videogames offer as a depression intervention? [03:43] Differences between the intervention and the control intervention [05:05] What was the impact of the interventions? [06:51] What were the limitations of the design and what might change going forward? [08:10] Does the patient’s perception of the effectiveness of the intervention matter? [09:20] How the intervention differs from a similar intervention aimed at children [10:19] Is there an advantage to “hiding” the intervention as a videogame? [11:33] Designing a game and an intervention that work simultaneously [13:27] What next for your research? [15:05] Kalin interview [16:11] Keefe et al. [16:22] Tabuteau et al. [18:15] Ge et al. [20:54] Pan et al. [22:01] Tamm et al. [23:47] Pizzagalli [25:30] Grogans et al. [26:02] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
27:58 6/30/22
June 2022: Structural Racism and Mental Health Disparities
AJP Editor-in-Chief Dr. Ned Kalin discusses the June issue with guest editor Dr. Crystal Barksdale (National Institute on Minority Health and Health Disparities). The issue focuses on mental health disparities, the pervasive negative consequences of structural racism, and the importance of community-wide and systemic interventions. Barksdale interview [00:30] How do mental health disparities differ for minoritized groups? [04:10] Structural and institutional racism as a factor in mental health disparities [05:53] Why have structural factors been largely ignored? [08:37] Alvidrez and Barksdale [11:03] Alegria et al. [13:11] Keeping review committees and reviewers up to date [15:11] Hankerson et al. [16:53] Developing research strategies based on the needs of the community [18:09] Alvarez et al. [20:22] What can the journal do to push these issues forward? [22:19]   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
25:45 5/23/22
May 2022: The Emergence of Psychiatry: 1650–1850
Dr. Kenneth Kendler (Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University, Roanoke, VA) discusses the history and emergence of psychiatry as a discipline, and how the conception of mind, body, and soul evolved. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses the May issue of AJP, and the past, present, and future of psychiatry. Kendler interview [00:45] Why is it important to look at the history of psychiatry? [10:28] The emergence of mental asylums [12:58] The mixed legacy of asylums [16:24] What’s next? [18:07] Kalin interview [21:14] Brennand [23:07] Erwin and Weinberger, Cruceanu et al. [24:29] Pretzsch et al. [26:04] Roberts et al. [27:17] Meier et al. [28:52] Pedersen et al. [32:02] In conclusion [33:55] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
35:57 5/1/22
April 2022: Effects of County-Level Opioid Dispensing Rates on Individual-Level Patterns of Prescription Opioid and Heroin Consumption: Evidence From National U.S. Data
Dr. Brian Kelly (Purdue University, West Lafayette, Indiana) discusses a study that found recent efforts to curb opioid prescriptions appear to have had an effect on reducing prescription opioid misuse and dependence, with no evidence that shifts in local-level opioid dispensing affected odds of heroin use, frequency of heroin use, or heroin dependence. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together. Kelly interview [00:30] Why county level data? [01:22] What accounts for the variation between counties? [02:28] Decreased prescription rates did not lead to increased heroin usage [04:07] How do we ensure the needs of those who need pain management? [04:55] What should happen with opioid dispensing practices? [06:10] National Survey on Drug Use and Health [07:30] Next steps [08:35] Kalin interview [09:34] Vuolo and Kelly [09:58] Watts et al. [11:25] O’Keeffe et al. [14:25] Sohal [17:35] Chung et al. [18:35] Summary [23:05] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
25:15 4/1/22
March 2022: Genetics and Brain Transcriptomics of Completed Suicide
Dr. Giovanna Punzi and Dr. Daniel Weinberger (Lieber Institute for Brain Development, Baltimore, Maryland) discuss findings from their new paper, “Genetics and Brain Transcriptomics of Completed Suicide,” which looks at differences in the brains of those who die by violent versus less violent means of suicide.  Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together. Punzi and Weinberger interview [00:43] What made the two categories distinct? [02:28] Aggression as a factor [03:43] Differences in genetic factors [04:58] Potential heterogeneity of suicide [06:28] Counterintuitive conclusions [07:42] Clinical implications for those at risk for suicide [11:00] Next steps for research [11:43] Kalin interview [12:56] McMahon [13:58] Jacquemont et al. [14:22] Mancini et al. [15:53] Mahjani et al. [18:40] Leckman [21:22] Punzi et al. [21:48] Ecker et al. [25:38] Summary [28:45]   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  
30:55 3/3/22
February 2022: Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD
Dr. Margaret Sibley (University of Washington, Seattle, WA) joins the podcast this month to discuss an article from the February issue of the Journal looking at patterns of remission in attention deficit hyperactivity disorder in children.  Dr. Ned Kalin, Editor-in-Chief of AJP will join us afterwards to discuss the rest of the February issue of the Journal. Sibley interview [00:51] What does “full remission” from ADHD mean? [01:54] Variable patterns of remission in children with ADHD [02:33] The DSM definition of ADHD and the impact of ADHD symptoms [04:10] Advantages and disadvantages of using longitudinal data [06:50] What does the pattern of intermittent remission mean for treatment of ADHD? [09:39] What does this suggest for further research into ADHD diagnosis and treatment? [11:08] How does this affect treatment going forward? [12:48] Kalin interview [15:25] Flavin et al. [16:04] Sibley et al. [16:45] Markowitz et al. [18:20] Tadmon and Olfson [19:07] Manfredi et al. [20:30] Morgan et al. [22:39] Cole et al. [24:57] In conclusion [29:03]   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
30:50 2/1/22
January 2022: Cannabis Use and the Endocannabinoid System
In this month’s AJP Audio, Dr Margert Haney (Director of the Cannabis Research Laboratory at Columbia Psychiatry) discusses her new review from the January issue of the American Journal of Psychiatry, “Cannabis Use and the Endocannabinoid System: A Clinical Perspective,” and the questions around the legal status of cannabis research.  Afterward, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the January 2022 issue of AJP. Haney interview: How does cannabis interact with our brains? [00:30] CBD and how it’s different [01:26] Impact of state legalization of cannabis on research [02:08] Federal attitudes towards cannabis legalization [03:43] A single source of cannabis for research [04:57] Limitations on research and an expanding, unexamined market [06:11] Marketing of other cannabinoids [06:38] Consequences of cannabis legalization [08:06] Cannabis use disorder [08:36] What happens with daily cannabis use – and abrupt cessation? [09:27] What happens to your endocannabinoid system with daily use? [10:36] A proliferating market and constrained research [11:56] Patients foregoing FDA-approved medication in favor of cannabis products [12:14] There’s a reason we have randomized controlled clinical trials with placebo [12:37] Changes in cannabis use and abuse [13:31] Public perception of cannabis use disorder [14:26] What’s next for cannabis research? [15:20] Loosening of cannabis sources [16:03] No US source for CBD to study [16:36] Future changes in the status quo? [17:24] Importance of the endogenous cannabinoid system [18:41] Potential consequences during vulnerable times in brain development: in utero and adolescence [19:08] Marketing cannabis to pregnant women [19:45] Kalin interview [20:30] Alcohol and cannabis use disorders [20:39] Haney [21:43] Browne et al. [22:34] Livne et al. [23:31] Mellentin et al. [25:38] Mallard et al. [27:39] In sum [28:30]   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  
30:20 1/4/22
December 2021: Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients
In this month’s AJP Audio, Dr. Samuel Wilkinson (Yale University, Associate Director of the Yale Depression Research Program) discusses a study looking at the association of electro-convulsive therapy or ECT on all-cause mortality and suicide in Medicare patients with mood and bipolar disorders.  Following that, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the December issue of AJP. Wilkinson interview: Effects of ECT on older patients with mood disorders [00:50] A brief history of ECT [01:20] A troubled history [02:00] A backlash against ECT [02:24] Improved techniques and practices [03:32] Limitations of past research into ECT [04:20] Strength of the study [05:33] How patients were matched [05:59] Limitations of the present study [07:17] Treatment of patients going forward [08:18] Difficulties in administering and accessing ECT [09:49] Next steps in research into ECT and patients with elevated suicide risk [11:14] All-cause mortality and ECT [11:57] Kalin interview: The December issue of AJP [13:02] Major depressive and bipolar disorders [13:13] “Neuromodulation Strategies for the Treatment of Depression” [13:42] “Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients” [14:19] “Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial” [15:29] Ostacher editorial [17:44] “Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies” [18:18] Pariante editorial [20:42] “Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis” [21:23] Putting the issue into context [23:00]   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  
25:33 12/1/21

Similar podcasts