Show cover of VOXLAB - The PrecisionTox Podcast

VOXLAB - The PrecisionTox Podcast

In the VOXLAB podcast series, Jeanne Laperrouze takes you on a journey towards precision toxicology. Listen to the voices of scientists across the globe working to advance life sciences and provide faster and more accurate solutions to understand the mechanisms of action of toxicants on human health. Discover what the theory of evolution teaches us about fruit flies, round worms, water fleas, zebrafishes and frogs and how we can harvest this knowledge to better protect all animals, including humans, and the ecosystems from the adverse effects of chemicals thanks to the power of phylogenetics and toxicology. The PrecisionTox Consortium gathers 15 research organisations from Europe and the US under the leadership of the University of Birmingham, united around the objective of tackling chemical pollution worldwide, the first cause of deaths in the world, without the need of mammalian animal testing.  The PrecisionTox project has received funding from the European Union's H2020 program (Grant Agreement n° 965406) to accelerate chemical risk assessment without the use of mammalian testing to better project human health and the environment. The content of this program only reflects the authors ‘view, the EU cannot be held responsible for any use of the information contained therein.   To learn more, visit our project website (https://www.precisiontox.org/)  and follow us on Twitter (https://twitter.com/PrecisionTox) : @PrecisionTox

Tracks

VOXLAB - Episode #5: Zebrafish model: from ecotoxicology to biomedical research
Thomas Dickmeis, from our partner organisation KIT introduces us to the use of zebrafish embryos in research. From ecotoxicology to biomedical research, discover the fascinating features of this popular fish and how scientists are using this robust 3Rs compliant model to advance the understanding of animal biology, including humans.
31:32 04/07/2022
VOXLAB - Episode #4: Xenopus embryos, a 3Rs compliant model for Human and environment health
Barbara Robin and David Du Pasquier, from the Laboratories WatchFrog in France, are the guests of this episode dedicated to the Xenopus embryos. This frog from Africa has gained a growing attention in the scientific community throughout the last decades for all the endpoints that it allows to study. Xenopus embryos consitute a model compatible with the objectives of reducing and replacing animal testing which can teach us a lot on the potential adverse effects of chemicals on human health, and thus in a ethical, faster and cost-effective way. Our guest will tell you more in this podcast.
31:13 03/22/2022
VOXLAB - Episode #3: Daphnia, a biodiversity time machine to protect humans and the environment
Prof. Luisa Orsini of the University of Birmingham introduces us to another fascinating organism model that serves both as sentinel in ecotoxicity as well as to predict the effect of chemicals on human health. Daphnia is a crustacean that lives in fresh waters that has the capacity to clone itself and enter stasis for centuries. Scientists use this model to understand biodiversity loss through times. These characteristics as well as the conserved genes that they share with humans throughout evolution also makes it a promissing model to replace mamalian models in toxicology to accelerate the identification of harmful chemicals. Discover how!
27:48 12/09/2021
VOXLAB - Episode #2: How C elegans is replacing mammalian models in safety testing
In this second episode of VOXLAB, the PrecisionTox podcast, Jeanne Laperrouze meets Prof. Jonathan Freedman from the University of Louisvilles (USA) to discuss the opportunities offered by alternative models to mammalian animals, such as C elegans to advance safety assessment of chemicals. This worm was the first organism whose DNA was fully sequenced. Since then, researchers have gathered extensive knowledge on this organism that the PrecisionTox consortium is now harvesting to transform toxicology from an observation discipline to a mechanistic science, to ultimately better protect human health and the environment. Discover how in this podcast and more! PrecisionTox  is a EU-funded project  (Grant Agreement n° 965406)  dedicated to tackling chemical pollution, the first cause of deaths in the world, without the need of mammalian animal testing.  To learn more, visit our project website and follow us on Twitter : @PrecisionTox
37:10 11/01/2021
VOXLAB - Episode #1: What Drosophila can bring to toxicology
Did you know that 60% of the Drosophila melanogaster (or fruit fly) genome is homologous to that of humans? That makes a valuable argument to use flies as a relevant model to study human health. Dr. Trudy Mackay, Director of Clemson University Centre for Human Genetics, explains how the theory of evolution and the advancement of genetics have led the PrecisionTox project to select Drosophila as one organism models to develop methods to accelerate chemical risk assessment to better protect humans and the environment and ultimately replace mammalian models. PrecisionTox  is a EU-funded project  (Grant Agreement n° 965406)  dedicated to tackling chemical pollution, the first cause of deaths in the world, without the need of mammalian animal testing.  To learn more, visit our project website and follow us on Twitter : @PrecisionTox
22:36 09/27/2021