X-Health.show - meet the future of healthcare

Currently: patients with breast cancer are adjusted to fit a table for radiotherapy.Soon: the table will be fitted to them.A personalized shell, 3D-printed for one specific patient, will be used for all radiation sessions.Less pain.More comfort.Shorter radiation sessions.In this episode, you will hear aboutthe benefits of radiotherapy in breast cancerradiotherapy for breast cancer side effectsand how clinical practice and a personal story motivate the founders EVERY DAYMy guest, Giovanna Dipasquale, is a co-founder and CEO of HeroSupport. A medical physicist with over two decades of experience in radiotherapy at one of the biggest hospitals in Europe, the Geneva University Hospital, where she led a study in 3D printing for radiotherapy.HeroSupport is a Swiss startup that is developing a personalized breast shell for radiotherapy in cancer treatment. Venus Shell allows for shorter radiation sessions, more comfort, and more precision.Follow them athttps://www.herosupport.care/ Please note: the shell is not yet available for patients but clinics may sign up for clinical trials. If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

12/10/24 • 52:12

People with spinal cord injury will be able to stand up and walk againwith this exoskeletonafter some trainingIn this episode, you will hearwhy TWIICE followed a strict rule of not allowing able-bodied people to test the exoskeletonhow they accelerated the development of the exoskeletonhow people after spinal cord injuries can move using itand moreMy guest, Dr. Tristan Vouga is a co-founder and CEO of TWIICE. He’s a robotic design engineer with a Ph.D. in wearable robotics from EPFL. TWIICE is a Swiss startup developing a modular lower-limb exoskeleton that enables people with paraplegia to stand up and walk again. Or take a hike up a snowy mountain. They completed their first clinical study with the Swiss Paraplegia Center.Go ahead and follow what they do athttps://twiice.ch/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

12/3/24 • 54:39

The goal is to have a breast cancer test at a point of care, say—at your family doctor’s office.And regularly.In this episode, you will hear aboutDNA origami and DNA as a building materialthe role of microRNAsand how a love for basketball led to becoming a DNA scientistMy guest, Dr. Ivana Domljanovic, is a postdoctoral researcher at the University of Fribourg and a scientist at Xemperia. She was awarded the Swiss Nanotechnology PhD Award for the invention of novel patented DNA origami biosensor.Xemperia is a Swiss startup, headed by Prof. Ruegg Curzio, on a mission to reduce breast cancer mortality by detecting and addressing cancer at its earliest stage. Ivana works there on developing a rapid blood test for breast cancer detection and the early detection of relapses.Go ahead and follow what they do athttps://xemperia.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

11/28/24 • 39:45

No email, no name, not even a login is required when signing up. You just start using the app so you don’t forget to take your meds.Wait, what?In this episode, you’ll hear about:a free medication reminders appwhy people don’t adhere to therapieshow patients control what they share and even earn moneyand how pharmaceutical and insurance companies can listen better to patients and support them with real-world data in cardiovascular, alimentary tract, metabolic diseases such as diabetes, nervous system conditions such as depression, and moreMy guest, Dr. Redona Hafizi is a co-founder and Head of Pharma at TOM Medications. With a PhD in industrial pharmaceutical science, she’s an expert in pharmaceutical insights. And guess what, they’re absolutely fascinating. TOM Medications is a Swiss startup that developed an app – for patients and with patients–to remind them to take their medications. The app is free. And already now, there’s a plethora of real-time patient data, valuable to pharmaceutical and insurance companies.Here’s when you can learn more about TOM:https://www.tommedications.com/Timestamps:00:00:00 Dr. Redona Hafizi and TOM Medications00:01:14 The Actual Profits of Using the App00:02:28 Setting Up the Medication Reminder App00:13:41 What Medication Adherence Means00:27:03 Iterating and Growing the App by Listening to Users00:32:27 Helping Pharma Be More Patient-Centric: Real-World Data, But Faster00:41:52 Checking for Double Medication with Insurance Companies00:47:20 Scaling Up to Make the Healthcare System More Patient-Centric00:50:58 Thank You, Follow TOM Medications00:52:08 Follow the X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

11/19/24 • 54:03

It is absolutely fascinating what impact such a simple, naturally occurring compound can have.An antioxidant that is 20-30 times more potent than vitamins C and E.And has the potential to protect brain longevity, including in cases of Multiple Sclerosis, Alzheimer’s Disease, Parkinson’s disease, after stroke, depression, spinal cord injury.In this episode you’ll hear abouthow the brain ages and when this process beginswhat are free radicalshow hydroxytyrosol, a natural neuroprotectant, workspre-clinical research in models for brain and spinal cord trauma, depression, Alzheimer's disease, Parkinson's diseaseMy guest, Prof. Roland Martin, is a co-founder of Noubrain and Cellerys. A world-class neurologist, specializing in neuroimmunology, renowned for his research into multiple sclerosis. His whole career working in academic institutions close to patients, in the US, Germany, Spain, and Switzerland.Noubrain is a Swiss startup that has developed neuroprotective supplements with hydroxytyrosol, a powerful antioxidant derived from olives and olive leaves. They have some promising unpublished pre-clinical results related to multiple sclerosis.Go ahead and follow what they do athttps://www.noubrain.ch/ – in German but you know what to do, hit that translate button in your browser ;-)Timestamps:00:00:00 Prof. Roland Martin and Noubrain00:01:18 Brain Aging00:08:08 What Are Free Radicals?00:12:40 Screening Compounds of the Mediterranean Diet00:15:50 What Is Hydroxytyrosol?00:25:29 Strong Antioxidant Supplement That Enters the Brain00:34:59 Research Behind Hydroxytyrosol00:46:35 New Antioxidant Availability00:51:51 Thank You Follow Noubrain00:52:40 Follow X-Health.show Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

11/12/24 • 54:35

It is not human tissue, i.e., it doesn’t come from a humanbut it is recognized by the body and well-tolerated.In effect, patients undergoing urethral stricture reconstruction have better recovery and less pain.In this episode, you will hear aboutregenerative medicineurethral stricture symptomsa scaffold that attracts the patients’ own cells surrounding the removed tissue and stimulates regenerationhow it dissolves itself, when the job is doneMy guest, Dr. Eva-Maria Balet, is a co-founder and CEO of Regenosca. She’s a biotechnologist with a PhD in Life Sciences from EPFL, a public research university in Lausanne. She has focused her research on scaffold design.Regenosca is a Swiss startup developing TissueSpan mesh – a technology platform to create regenerative, off-the-shelf meshes for soft tissue repair. Their first indication is urethral stricture – first-in-human implantations show shorter surgery time and less pain for patients.Here’s more about them,https://www.regenosca.com/Timestamps:00:00:00 Dr. Eva-Maria Balet and Regenosca00:01:18 Bridge That Helps Tissue Healing00:02:49 Innovation Behind the Scenes00:05:03 Urethra Reconstruction: Gold Standard00:07:05 What Is Urethral Stricture00:12:50 Collagen-Based Scaffold for Urethra Narrowing Reconstruction00:16:34 How Does TissueSpan Mesh Work00:22:18 First-In-Men Studies in Malaysia00:31:32 Planning the Startup Growth00:44:35 Thank You, Follow Regenosca00:45:05 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

11/5/24 • 47:00

How does your health tracker fit into your style?Well, my guest today wasn’t happy with how her plastic-looking health tracker did not match her Rolex. But longevity was important to her. Connecting the dots, she started developing a smart strap. To her Rolex. Or Omega, Gucci, Patek Philippe – any traditional watch you fancy.In this episode, you will hear abouta health tracker that matches your stylehigh-end vulcanized rubber used for this smart strapwhat you can track with a smart strap health trackera startup collaboration with CSEM or Swiss Center for Electronics and Microtechnologyand how a smart strap can save the traditional watch industryMy guest, Olga Nijpels-Tishurova, is the founder and CEO of Watchibia. She’s combined her experience in the electronics industry with her love for luxury watches and aesthetics, and a focus on extending healthspan.Watchibia is a Swiss startup that develops a smart strap for traditional watches. Think, wearing your favorite watch, a Rolex, Omega, Gucci, Patek Philippe, whatever you fancy, and simply changing the strap to track your health. No additional fitness tracker needed.Go ahead and follow Watchibia on Instagram https://www.instagram.com/watch_ibia/ and Olga on LinkedIn: https://www.linkedin.com/in/olga-nijpels-tishurova-b211a219/Timestamps:00:00:00 Olga Nijpels-Tishurova and Watchibia00:01:22 Why Olga Dropped a Plastic Health Tracker00:05:09 The Idea for a Smart Strap for a Rolex00:11:43 What Is the Smart Strap00:19:27 Developing the Smart Strap for Longevity00:25:40 Saving the Traditional Watch Industry00:37:55 Thank You Follow Watchibia00:38:43 Follow X-Health.show Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

10/22/24 • 40:38

Will we, in the future, be detecting diseases using extracellular vesicles?Will these diagnostics replace MRI or CT?In this episode, you’ll hear aboutthe personalized medicine of the futurewhat is nanomedicinehow to isolate pure extracellular vesicleswhat are extracellular vesicles and how they compare to stem cell treatmentsMy guest today, Dr. Adva Krivitsky, is a co-founder and the CEO of Acytronix. She’s both a biologist and a chemist by training and completed her PhD in nanomedicine: polymer therapeutics, RNA delivery, and cancer research.Acytronix is a Swiss startup that developed a portable microstructured electrochemical device to isolate extracellular vesicles in less than 10 minutes. These extracellular vesicles can be key in detecting and treating diseases–more gently–in the future.Here’s more about Acytronix:acytronix.ch If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

10/16/24 • 40:02

Take a wild guess: how many years will you get back when you limit your screen time?Yes, I said: YEARS.Spoiler: more than you think. But my guest gives an exact number.Because in this episode, you’ll hear abouta phone addiction – or “problematic phone use” if you preferhow to tell if you’re addicted to your phonehow to break a phone addictionand how a screen time app can helpMy guest, Ondrej Zak is the CEO of Zario. He’s got a solid background in advising on digital transformation, new business models, and creating digital products.Zario is a Swiss startup that developed an app to help us regain control over our digital habits. Think: screen time, scrolling – you get the idea. It uses behavioral psychology and gamifies experience to promote sustainable habit change. Already available in both the App Store and Google Play Store check them there or go to their website:https://www.meetzario.com/Timestamps:0:00 Ondrej Zak and Zario1:19 Tinder Match at a C-Level Meeting3:53 Cheating on Self-Imposed Phone Restrictions6:12 Average Screen Time13:59 How to Check Screen Time On iPhone, How to Check Screen Time on Android17:45 Testing the Zario Screen Time App23:58 How to Know if I Am Addicted to My Phone32:19 Use Social Media Methods to Make You Unhooked38:25 Zario Team, London School of Economics and Lucerne University46:29 Thank You, Follow Zario46:58 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

10/8/24 • 48:19

80% of people who lost weight, kept that weight off after two years.But quite a few did not even start.Those who did, did not follow any particular diet.People are too individual to follow one diet.They did not count calories.People hate counting calories.They love healthspan.They love longevity.What science-backed solutions work?In this episode you will hear about4 simple rules you will want to follow to lose weightwhy most people would NOT follow on themhow one of the co-founders lost 40 kilosand how LEALY achieved an 80% success rateMy guest, Dr. Julia Vogel Wenzin is a co-founder and the CEO of Lealy. She holds a Ph.D. in Computer Science, Computer Vision, and Machine Learning and has a track record of designing digital solutions.Lealy is a Swiss startup that helps overweight people lose weight. Not by offering any miraculous diet. With the origins at a Swiss private clinic, they now offer in their app a blended care habit change program. Currently available in Switzerland.Check out their website in Germanhttps://www.lealy.health/Timestamps00:00:00 Julia Vogel Wenzin and LEALY00:01:09 Two Years to Lose Weight00:02:40 What Is Overweight00:05:55 40 Kg Permanent Weight Loss00:14:06 Blended Weight Loss Program With No Yo-Yo Effect00:20:30 Why More Women Than Men Seek to Lose Weight00:35:10 How Much Will You Pay To Lose Weight00:43:55 Thank You, Follow LEALY00:44:13 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

10/1/24 • 46:08

Cultured meat or cultivated meat, made from cells, is not science-fiction any more.It is pure science.Though I could not help but thinking about Nancy Kress science-fiction book Beggars and Choosers when preparing to this episode. She writes about a world in 2106 where the society is split into a ruling class of Donkeys, who have access to real food, and Livers, who rely on government-provided cheap synthetic and soy-based food. It's just, the current reality of cell-grown meat already looks way more promising than the one in Kress's 1994 novel.What if cultivated meat is healthier and tastes better than meat an animal meat?Would you be tempted by a tasty steak grown in a lab?In this episode, you’ll hear aboutwhat is cultivated meat?why it’s called lab meat and beer isn’thow meat is cultivated from cellsdoes it taste like meathow healthy is itand much more.So today’s story isn’t about a medtech, biotech or digital health startup but it did begin with medtech in mind. And it is absolutely fascinating.My guest, Dr. Nicole Kleger is the CEO of sallea. She began working on this project during her Bachelor’s degree in Materials Science and continued through her Master’s and Ph.D. She’s also a deidcated instructor of Bodypump, Bodyattack, and Bodybalance.sallea is a Swiss startup, an ETH Zurich spin-off, developing edible scaffolds to grow cultivated meat. Their scaffolds, which enable cells to grow into meat, promise your taste buds real meat experience – without sacrificing animals.Check out where is sallea on their goal to match the meat structure with taste in cultured meatgo to https://sallea.ch/Timestamps00:02:40 Why Cultivate Meat From Cells?00:04:19 What Is Cellular Agriculture?00:05:18 Where Is Cultivated Meat Produced?00:06:54 How Healthy Is Cultivated Meat?00:08:42 What Does Cultivated Meat Taste Like?00:12:02 From Medtech To Food00:19:00 What Is Cultivated Meat?00:26:26 The Team Behind Swiss Cultured Meat00:41:00 Thank You Follow sallea00:41:46 Follow X-Health.show Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

9/24/24 • 43:42

If you've ever given up on something because you thought you didn’t have the predisposition, you should listen to this episode.From sports genomics to genetic-based training.Can genes predict sports performance? And injuries in athletes?What is the contribution of genes to sports performance? We're speaking percentages.Can some athletes be too gifted?Can you predict a child’s talent by analyzing their genes?We’ll also be speaking about multiomics: genomics, genetics, proteomics, metabolomics, microbiomegenetic testing for athletes, rare diseases, and longevityidentical twins researchalthletes such as LeBron James, Michael Phelps, and Imane KhelifMy guest, Thomas Roos, is a sports genetics and genetic epidemiology scientist, entrepreneur, a retired professional triathlete, and an identical twin. He studied at Stanford University School of Medicine and has conducted research as part of multiple international consortiums.AISTS or International Academy of Sports Science and Technology, where we’re speaking, was founded by the International Olympic Committee. It brings together experts in medicine, technology, management, economics, law, and sociology.There’s loads to cover in this episode.Timestamps:00:00:18 Thomas Roos and AISTS00:01:19 What Can Your Genes Tell You About Longevity Your Health and Performance00:03:05 Can Genes Predict Athletic Performance00:06:05 Identical Twin Brothers' Genetics00:09:37 Genetic Tests for Children's Talents – Do They Make Sense00:14:02 Genetics and Genomics Definitions00:17:50 What Is Multiomics00:20:51 Genetic Tests for Athletes00:30:22 Genetic Risk Scores for Athletes00:38:19 Favorable Genetic Profiles and Success in Sports00:50:08 Twin Brothers Part After 30 Years: Stanford Twin Research Cohort01:02:12 Joint Research to Beat Alzheimer's01:13:25 Thank You Follow 5 Ironmans To Beat Alzheimer's01:14:38 Follow X-Health.show Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

9/17/24 • 76:33

By helping pumping blood, Ventricular Assist Devices during end-stage heart failure can prolong life. They can be implanted instead of a heart transplant or while waiting for a heart transplant. They may, however, come with some unwanted side effects, such as infections of a wound that doesn’t heal. The reason is that a cable connecting the Ventricular Assist Device to its power source must pass through the skin on the abdomen and remain there.This wound, a small hole in the abdomen, where the cable goes through the skin, would not heal and is therefore susceptible to infections that lead to hospitalization. Why?You’ll hear about it in this episode, as well aswhat Ventricular Assist Devices arehow a wound heals – from mechanical perspectivewhat are mechanical and biological properties of the skinwhat is end-stage heart failurewhat makes a skin-friendly cableand for what else could such a biocompatible cable be usedMy guest, Dr. Andreas Kourouklis, is a co-founder and the CEO of COSKIN. With a Ph.D. in biomaterials for biomedical applications he worked at Princeton University and University of Illinois at Urbana-Champaign before joining ETH Zurich.COSKIN is a Swiss startup that develops a biocompatible medical cable to support end-stage heart failure patients. Unlike today’s cables powering mechanical circulatory support systems such as VADs, it resembles human tissue and prevents infections. Go ahead and follow what they do athttps://www.coskindevices.com/Timestamps:00:00:00 Dr. Andreas Kourouklis and COSKIN00:01:20 What Is End-Stage Heart Failure?00:06:47 Current Treatment for End Stage Heart Failure: Ventricular Assist Devices00:15:02 Challenges Regarding VAD Insertion00:21:23 Developing a Biocompatible Cable00:40:28 Proving Compatibility with Ventricular Assist Devices00:49:15 The COSKIN Team00:49:59 Other Possible Uses of the Biocompatible Cable: Neurostimulators, Catheters, and More00:53:42 Thank You, Follow COSKIN00:54:24 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

9/10/24 • 56:19

This might be a tool that sports psychologists have dreamed of:a way to measure athletes’ mental training efficacyfor boosting sports performance.You know, like when a runner runs slower today than the day beforetheir coach has the data to compare.If that same runner puts less effort into their mental training,their sports psychologist would not know.This is what my guest is working on,giving mental coaches a VR headset and metrics to rely onto help athletes find flow and improve sports performanceYou will hearwhy do professional athletes need mental trainingwhat flow ishow your pupil size changes when you are relaxed or arousedand how by controlling your pupil, you can control your mindDr. Marc Bächinger is the co-founder and CEO of MindMetrix. He is a neuroscientist with a Ph.D. in health sciences and technology who completed his postdoc in pupil-based biofeedback to modulate the arousal system in the human brain.MindMetrix is an early-stage Swiss startup that develops myflow. This Virtual Reality application allows professional athletes and sports psychologists to track, analyze, and optimize mental training by giving feedback on the size of their pupils.Follow myflow’s development and their current call for study participants athttps://www.myflow.ch/Timestamps:0:00 Dr. Marc Bächinger and myflow1:19 What is Flow?7:28 Mental Training in Professional Athletes13:08 How to Measure Mental Training Efficacy17:03 Locus Coeruleus Pupil and Control Over Arousal Level24:01 Family History and the Pursuit of Neuroscience26:18 Sports Psychologists and Training the Pupil33:20 VR-Supported Biofeedback Method for Relaxation and Activation39:28 Noa Loosli Swiss Football Player45:42 Call for Study Participants48:02 Thank You Follow myflow48:28 Follow X-Health.show Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

9/3/24 • 49:50

We are speaking about the world where wheelchairs will not be needed after a spinal cord injury.There are 250 000-500 000 spinal cord injuries globally each year.“A bunch of crazy guys,” in the words of my guest, him included, wants the spinal cord to self-regenerate.He is sure that in the future, we won’t be even speaking about regenerating the spinal cord after an accidentbut about healing.In this episode, you will hearhow much time it takes from a spinal cord injury event, an accident, to reach an operating theatre – in Switzerlandwhy this time is crucialhow proprietary hydrogel and stem cells stop the cascade of events further damaging the spinal cordhow mice after a spinal cord injury, could walk againand when will people after the spinal cord injury not need a wheelchairProf. Giuseppe Perale is the CEO of Regenera. A bioengineer who became hooked on regenerative medicine in high school and never let go. Apart from heading the neuroregeneration research lab at USI, Università della Svizzera italiana, he is also a motorcycle rider and a pilot. Regenera is an Austrian-Swiss startup that aims to repair spinal cord injury in the subacute state. Their SpinoSave combines biomaterial – hydrogel and stem cells harvested from the patient’s fat tissue. The co-founders are Giuseppe Perale; Filippo Rossi, a chemical engineer; Pietro Rossi; Michael Raghunath, CMO.Visit their website to stay up to date with progress in regenerating the spinal cord:https://regenera.at/Timestamps:0:00 Prof. Giuseppe Perale and Regenera1:10 Making Paralysis a Thing of the Past3:17 What Causes Spinal Cord Injuries5:44 What Is Paraplegia, What Is Tetraplegia10:02 What Happens in the ER after a Spinal Cord Injury17:56 Regenerative Medicine to Restore Damaged Tissue26:59 Paraplegic Mice Could Walk Again, When Will People 35:35 Why Time Matters after a Spinal Cord Accident39:21 Stopping the Cascade of Events in the Acute Spinal Cord Injury Phase to Induce Self-Regeneration54:36 Preparing for Clinical Studies56:55 Restoring Movement after Spinal Cord Injury in the Future1:00:29 Thank You, Follow Regenera1:01:25 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

8/27/24 • 62:46

How do you design a psychedelic trip that is predictable and effective?That frees people from cocaine addictionWithout the common current side effects of psychedelicsJust imagine being free from an addiction in a few hoursThis is what researchers and my guest today are trying to accomplishYou’ll hearhow did psychedelic studies continue in Switzerland while banned elsewherethe differences between various psychedelicswhat is ayahuasca and its DMT ingredienthow do magic mushrooms and psilocybin workLSDecstasyand the potential of psychedelics in treating depression, anxiety, and cocaine addictionMy guest, Dr. Dario Dornbierer, is the Chief Scientific Officer and a co-founder of Reconnect Labs. A psychopharmacologist who’s done his post-doc research in psychedelics – drug development in mental health.Reconnect Labs is a clinical-stage Swiss startup, a spin-off of the University of Zurich, developing psychedelic medicines for sleep, anxiety, and substance use disorders. This opens a new era in psychiatry: precision therapeutics with both immediate and long-term symptom alleviation.Hit play to step into a sleep lab, where it all started.Learn more about Reconnect Labs at:https://www.reconnect-labs.com/Timestamps0:00 Dr. Dario Dornbierer and Reconnect Labs1:19 Where Are Psychedelics Legal: LSD, Psylocybin, Ayahuasca3:40 Psychedelics to Aid Psychiatry6:02 What Are Psychedelics?12:45 How Do Psychedelics Work?16:03 What Is Ayahuasca? 20:59 The Potential of Psychedelics in Depression, Anxiety, Addictive Disorders26:40 Psilocybin vs DMT and Harmine28:29 Set and Setting of a Psychedelic Trip36:48 Developing a Predictable Trip with a Therapeutic Effect42:28 Treating Addiction with Psychedelics1:00:59 Thank You, Follow Reconnect Labs1:01:53 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

8/20/24 • 63:14

There are people who believe that stopping aging will be possible.For now,we can already speak aboutslowing down agingor evenreversing aging – as Bryan Johnson set off to accomplish waving his "Don't Die" slogan.In this episode, you’ll hear aboutis collagen good for you?vegan collagen precursorat what age the production of some coenzymes slows down – meaning how early your body begins to age – you will be surprised how early!NMNcoenzyme Q10, resveratrol, probiotics, melatoninas well as skin healthjoint health blood sugargut and brain healthenergyand overall, longevity and healthspanMy guest, Sophie Chabloz, is a co-founder and Chief Science Officer at AVEA. A Food Science, Nutrition and Health expert. A mom. Used to teach yoga. She makes sure the supplement formulations make sense.AVEA is a Swiss startup that launched a range of science-based longevity supplements. Among them, their collagen activator – a vegan collagen precursor.Here is where you can find them:https://avea-life.com/Timestamps:0:00 Sophie Chabloz and Avea1:14 Is Collagen Good for You?10:52 What Compounds and Coenzymes Do We Lose When Aging?16:35 Melatonin as an Antioxidant21:36 Supplements vs Nutraceuticals26:28 Vegan Collagen Precursor38:36 Improving Joint Health40:41 Science Behind Longevity Supplement Formulas49:27 Longevity Supplements Shipped Worldwide55:14 Thank You, Follow Avea55:42 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

8/13/24 • 57:03

Fetal surgeons save the life of a fetus with a birth defect– or improve the outcomes after birth –operating while still in utero.In a woman’s womb.Unsolvable so far – a hole in an amniotic sac after the surgerywhich causes preterm births.But here is where bioengineers have stepped into support the surgeons.In this episode, you’ll hear about fetal abnormalities that can be addressed by surgeries before a child is bornspina bifidatwin-to-twin transfusion syndromecongenital diaphragmatic herniahow fetal surgeries are performedand how to prevent the side effect of fetal surgery, which is premature birthOur guest, Dr. Yannick Devaud is the founder and CEO of KOVE medical. With a PhD in bioengineering and biotechnology, he embarked on a mission to develop a medical device for minimally invasive fetal surgery.KOVE medical is a Swiss startup that develops a device to reduce the risk of preterm birth following surgeries on the fetus during pregnancy.Here is more about themhttps://kovemedical.com/Timestamps:0:00 Dr. Yannick Devaud and KOVE medical1:20 World Fetal Medicine Foundation Congress in Lisbon3:06 What Are Fetal Surgeries13:03 Risks of Fetal Surgeries17:44 Calling a Bioengineer to Prevent the Premature Birth26:39 How to Stitch a Whole in an Amniotic Sack After a Fetal Surgery28:45 Collaborations with the University Hospital Zurich and Centers Around the World35:31 Future of the KOVE Device to Support Fetal Surgeons46:27 Thank You, Follow KOVE medical47:16 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

8/6/24 • 48:37

The pain in your mouth is so bad that you cannot even drink, let alone eat.What is horrifying is that 50-80% of cancer patients undergoing chemo or radiotherapy can experience it – oral mucositis.And there is no approved treatment.This is what you’ll hear in this episodehow a cute-looking willowherb grown in the Swiss Alps is making its way from traditional medicine to prescription medicine – to treat oral mucositis, especially in cancer patientsand in the long term, more broadly – fungal infectionsMy guest today is Dr. Pierre Morgon, the CEO of Ibex Therapeutics. With a PhD in pharmacy, he has held numerous senior positions in the life sciences industry and currently serves on the boards of biotech, medtech, and healthcare IT startups.He decided to co-found Ibex Therapeutics, a Swiss startup that aims to alleviate the debilitating oral pain that often results from chemotherapies and radiotherapies. To combat oral mucositis, they employed a plant native to the Swiss Alps.Here’s more about them if you’re curious:https://ibextx.ch/en/Timestamps:0:00 Dr. Pierre Morgon and Ibex Therapeutics1:18 Willowherb from the Swiss Alps3:00 What is Oral Mucositis11:01 Discovery of Epilobium Parviflorum Antifungal Properties: the Discovery 20:49 Clear Unmet Need + Experienced Founders25:32 Mouth Wash for Oral Mucositis: First Studies in Patients33:34 Market Availability: Cosmetic and Pharmaceutical Products43:15 Plant-Based Medicine49:02 Thank You, Follow Ibex Therapeutics 49:34 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

7/30/24 • 50:55

Do you know what is the % of cancer drug candidates that fail in human trials?Guess, and I bet you underestimated it.This is what we speak at the beginning of this episode and what my guest wants to change dramatically.You will also hear about:the % of patients that actually benefit from approved cancer drug therapies (spoiler: so so low)cancer monotherapies vs. cancer combination therapieshow to reproduce the human cancer ecosystem from a tumorprecision oncologymultiomics analysisand how to bring cancer drugs faster to patientsDr. Marie-Agnès Doucey, the co-founder of Calico Biosystems, is a biotechnology engineer with a PhD in biochemistry.  She has over 15 years of experience in R&D and drug development programs in oncology.Calico Biosystems is a Swiss startup developing a drug testing platform that uses patients’ tumors, multiomics profiling, and computational modeling to predict the clinical efficacy of anti-cancer drugs at the pre-clinical stage. Radically accelerating drug development.Here is their website:https://calicobiosystems.com/ 0:00 Dr. Marie-Agnès Doucey and Calico Biosystems1:15 Why Only 10% of Cancer Patients Benefit from Therapies9:00 Complexity of Experimental Oncology12:50 Cancer Monotherapies vs. Cancer Combination Therapies15:11 How to Reproduce Human Cancer Ecosystem17:10 What is Precision Oncology20:35 Platform for Cancer Drug Developers Instead of Animal Models32:34 Collaboration with the University of Lausanne37:49 What is Multiomics Analysis40:35 De-risking Clinical Studies and Moving to the Clinical Stage47:16 More Than a Decade of Research to Found a Startup53:07 Thank You, Follow Calico Biosystems53:55 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

7/23/24 • 55:16

Think: an insulin pen but for solid drugs. Like, you are sure how much you administer EACH time.Like, you do not split the tablet in 3 worrying if this is 1/3 or closer to 1/4. And if that matters.One study showed that 1 in 4 caregivers gave a dose that deviated by more than 40%. And more studies point to drug administering errors.In this X-Health.show episode you’ll hear aboutan engineer’s idea that immediately got pediatrists on boardhow to administer a drug more preciselyfor both children and adultshow the idea was bornand why it is good to fail with first tests as much as you canMy guest, Thierry Jomini, is the CEO and founder of Abbatia Labs. A mechanical engineer with 15 years of experience in leading drug delivery device development for Parkinson’s, hormone therapies, or injectable pens for diabetes.AbbatiaLabs is a Swiss startup that works on POWDOSE, a pre-filled dosing device for solid oral drugs. The aim is to reduce the risk of, now happening way too often, dosage errors, enabling more precise dosing based on body weight, gender, and condition.Follow them at:https://www.abbatialabs.comTimestamps:0:00 Thierry Jomini and AbbatiaLabs1:19 Errors in Administering Drugs to Children5:17 Adults' Problems with Dosing8:17 Types of Drug Delivery Devices11:11 POWDOSE Delivery Device for Solid Drugs20:28 Partnerships with Pharmaceutical Companies30:56 Paediatric Formulations Studies with the University College of London37:31 First Testers of the Solid Drug Distributor41:00 Chicken and Egg Situation of a Startup Introducing New Medical Device46:50 Thank You, Follow AbbatiaLabs47:21 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

7/16/24 • 48:42

How long are you willing to stay in psychotherapy?Or do you want to just get better?This is what Joy wanted.To get better – faster.As a bioinformatician, she worked with big data setsand could not accept that in her psychotherapy she depended on paperwork, as if it was still the 20th century.You’ll hear in this episodewhat is digital phenotypingwhat passive digital data do you generate on your smartphonehow it can be used to support your mental wellbeing and connect a therapist with a patient betterYou will also have a better understanding of Gen Z’s mental health needs.My guest today is Joy Bordini, the CEO of Go Healthy. A powerhouse really that has a rare ability to understand both emotions and complex tech. Specializing in AI and bioinformatics, she used to perform whole genome and exome sequencing, working on complex data sets.Go Healthy & Co. is an early-stage Swiss startup that supports diagnosis and therapy response analysis in mental health by using digital phenotyping. Their software is meant for clinics and mental health providers and in the end, to serve both patients and therapists.And here’s more about Go Healthy:https://gohealthyandco.com/en/home/Timestamps:0:00 Joy Bordini and Go Healthy1:14 Dropping Out of Psychotherapy11:25 A Techie + F2F Therapy = a Startup Idea 15:01 Mental Health Chatbot and Why It Did Not Work18:39 What is Digital Phenotyping: Passive Data and Active Data26:09 Analysing Behavioral Data29:19 Aligning a Therapist with a Patient – Digitally37:26 Co-development with Clinics to Integrate with Current Processes40:28 Learnings from the Silicon Valley53:29 Thank You, Follow Go Healthy54:20 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

7/9/24 • 55:16

Managing diabetes is complex enough, adding sports on top of it seems too much for many. But what if you had an app that would help?You’ll hear aboutthe physiology of exercising with type 1 and type 2 diabeteswhat can go wronghypoglycaemia and hiperglycaemiaketoacidosistools to use to take control of the glucose level and do sports seriously, like there weren’t out there beforeMy guest today is Dr. Sam Scott, the Chief Scientific Officer at Enhance-d. An exercise physiologist with a vast background in researching diabetes and exercise in the UK, Canada, and Switzerland. He is an Advisor on the Exercise Physiology interest group leadership team for the American Diabetes Association. He used to be the Head of Research for Team Novo Nordisk the world’s first all-diabetes professional cycling team. Enhance-d is a Swiss startup that develops an app for people with diabetes to exercise and even do professional sports safely by giving actionable, individualized insights drawn from a plethora of diabetes and exercise data.Here you may follow their Beta and finale app release:https://www.enhance-d.comTimestamps:0:00 Dr. Sam Scott and Enhance-d1:18 Supporting Pro Athletes with Type 1 Diabetes6:23 Blood Glucose Level When Exercising13:08 What is Hypoglycemia, What is Hyperglycemia14:51 What is Ketoacidosis16:17 Exercising with Diabetes: What to Consider22:25 HIIT High Intensity Interval Training and Diabetes30:01 Professional Cyclist Team with Type 1 Diabetes35:00 Exercise App for People with Diabetes48:52 Thank You, Follow Enhance-d, Join Beta Testing49:46 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

7/2/24 • 51:07

If you are a person with diabetes, you already know that some drugs cannot be administered other than via injections. Today’s guest works on a solution for these medications to be taken from the inside of the cheek.You’ll hear:how different kinds of drugs are absorbedwhy some drugs, macromolecular drugs, such as the ones for diabetes, need to be delivered in injectionshow Obaris has overcome this problemhow drugs such as Ozempic or Mounjaro could be administered painlesslyDr. David Klein Cerrejon is the CEO of Obaris, a chemist with a PhD in pharmaceutical science specializing in drug delivery.Obaris is a Swiss startup, an ETH spin-off, that develops Octo-Patch, a small, painless patch, resembling an octopus sucker, that you can stick to the inner side of the cheek to administer drugs that are now available only in injections.Here is more about Obaris:https://obaris.ch/Timestamps:0:00 Dr. David Klein Cerrejon and OBaris1:13 Why Diabetes and Osteoporosis Drugs Have to Be Injected (Currently)7:02 Peppercorn at the Root of Peptide Drugs Delivery via Inside of the Cheek11:53 Nature-Inspired Shape: Octopus Sucker for a Suction Cup17:27 Future of Drugs Such As Ozempic or Mounjaro Administration27:09 Shifting the Paradigm in Peptide Drug Delivery35:47 Drug Combination Development Roadmap44:34 Thank You, Follow OBaris45:00 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

6/25/24 • 46:21

The small amount of brown fat can make you slim. Too much may kill you. We just don't know who has it and how much. But this may change with this test.You’ll hear aboutbrown fat but also white fat and beige fatwhat happens when we have too much brown fat or too littlea new contrast agent to see brown fat on a CT scanthat allows targeted therapies for cancer, diabetes, obesity,and even longevityDr. Andrej Babic is the CEO of Adiposs. A pharmacist with a PhD in medicinal chemistry who developed molecules for the diagnosis of diabetes, obesity, and cancer at the University of Geneva. He holds patents in medical imaging, photodynamic therapy, and nanotechnology.Adiposs is a Swiss startup that develops ImageBAT, a first-in-class CT contrast agent for brown fat. This can be a game changer in obesity treatments, metabolic diseases, diabetes type 2, and cancer.Note where to find them:https://adiposs.comTimestamps:0:00 Dr. Andrej Babic and Adiposs1:54 What is Brown Fat vs White Fat6:38 Researching Brown Fat in Metabolic Diseases16:38 How Does the Contrast Agent for Brown Fat Work19:42 Personalised Treatment in Cancer and Metabolic Diseases Targeting Brown Fat30:04 Wasting Syndrome in Cancer34:40 Inducing Brown Fat for Obesity Treatment in Preclinical Studies38:05 Moving into Clinical Trials to Detect Brown Fat for Targeted Obesity, Diabetes and Cancer Treatment50:34 Thank You, Follow Adiposs51:33 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

6/18/24 • 52:54

He dropped his engineering job to run 5 Ironman triathlons in 5 countriesfor a cause.But he did not foresee he would gather so many scientists on the waythat try to find a way to mitigate dementiaYou’ll hearwhat does it take to run an Ironman triathlonhow his family coped with his father’s Alzheimer’show he united several startups and researchers to launch a study on the impact of lifestyle on the epigenetic level – to mitigate dementiaMy guest today is Hassan Fadli, a materials engineer with 20 years of experience as a technology lead in the solar energy industry. But we’re not going to speak about photonics. His family history made him turn his life upside down.He’s founded "5 Ironmans to Beat Alzheimer’s”, a non-profit initiative to run 5 Ironman triathlons in 5 countries in one year. They film a documentary about it, also interviewing dementia specialists, societies, patients, and families in all these countries. After Switzerland and Portugal, there are 3 races ahead in 2024: in France, Nice – on June the 16 UPDATE: finished and beat his record!in Sweden, Kalmar – on August the 16and Spain, Calella-Barcelona – on October the 6thFollow his Ironman races at:https://www.5ironmansbeatalzheimer.com/enTimestamps:0:00 Hassan Fadli and 5 Ironmans to Beat Alzheimer's1:13 Assignment from Father Who Had Dementia Diagnosis9:30 5 Ironman Triathlons Because Alzheimer's is Tough16:42 What is Ironman25:24 Taking Scientists Onboard to Mitigate Dementia36:23 Alzheimer's Prevention Starts at School41:39 Ironman Races Ahead48:29 Thank You, Follow 5 Ironmans49:00 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

6/11/24 • 50:21

Can the Dark Genome have the answer to any disease?And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating.Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases.With the potential to cure them completely.Today we are speaking about heart fibrosis and also:the richness of the regulatory genomeits function: as a kind of software for the human bodyRNA therapies that are targeted, non-toxic, fast in developmentan absolutely new approach to drugsDr. Samir Ounzain is the CEO of HAYA Therapeutics. A molecular biologist who’s researched dark genome and its roles for over 15 years. While a postdoc at Lausanne University Hospital (CHUV), he discovered hundreds of long-non-coding RNAs.HAYA Therapeutics selected one of them, called Wisper, to develop a highly targeted drug to address cardiovascular disease. That's  for starters. They already work on lung fibrosis, cancer microenvironment, liver, pancreas, and kidney. 3 months after we aired this interview, they signed $1 billion multi-year collaboration with Eli Lilly to target obesity and related metabolic conditions. They are based in both Lausanne, Switzerland and San Diego, US.https://www.hayatx.com/Timestamps:0:00 Dr. Samir Ounzain and HAYA Therapeutics1:14 Over 90% of Human Genome is Called Dark Genome7:12 What is the Dark Genome8:12 What is Epigenetics11:41 Why Are Humans Different from a Fly17:56 Most of Chronic Diseases Are Found in Dark Genome20:17 Types of RNA: Messenger RNA, Non-Coding RNA26:40 Building the Atlas of Cardiovascular Disease Dark Genome30:30 Fibrosis and the RNA Called Wisper38:33 How Can RNAs Be Used As Medicine42:37 Pre-Clinical Results in Heart Fibrosis: When You Block Wisper RNA45:22 Start of Studies in Humans of First in Biology Drugs47:21 HAYA's Atlas of Dark Genome and Search Engine51:28 HAYA in both Switzerland and the US58:34 Thank You, Follow HAYA59:42 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

6/4/24 • 61:03

Haven’t heard about breathing rate tracking yet?Listen up.You won’t need much to improve running:just your headset and an app.In this episode, you’ll hear abouttraining plans based on breathingteaching ML models to recognize breathing patternshuge breathing data setsand how will you be able to use them to improve running and your training efficiencyDr. Patrick Helfenstein is the co-founder and Chief Technical Officer at BreezeLabs. A physicist originally, with over a decade of research experience in both academia and industry he embraced Machine Learning. Just wait until he starts speaking about it. BreezeLabs is a pre-seed stage Swiss startup that promises runners better optimised training by adding breathing rate tracking. No additional wearable needed, just a headset with a mic and their AI models will do the rest.Here’s more about them:https://www.breezelabs.ai/Timestamps:0:00 Dr. Patrick Helfenstein and BreezeLabs1:13 Wearables for Runners and What Can You Rely On9:23 Breathing and Exercise12:34 Tracking Breathing with Your Headset18:09 The Biggest Breathing Data Sets in the World21:52 Machine Learning and Artificial Intelligence Basics44:34 Thank You, Follow BreezeLabs45:46 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

5/28/24 • 47:07

Challenging an over 100-year-old histology technic that is prone to false negatives.In cancer diagnostics.My guest aims to take histopathology departments from the 20th century into the 21st century, where they belong.From slicing biopsy samples into 3D.From a manual preparation to a robotic one.Where all abnormalities will be pointed out and counted by AI.And human physicians will see inside the whole sample in 3D.Let's get down to the cell level.You’ll hearwhat happens to your biopsy sampleswhy the current histopathology standard is prone to misseshow do you see inside the tissue in 3D and see 400 times more cellswhat’s so fascinating about watching cells and tissues under the microscopeand more Dr. Francesca Catto, the CEO of IMAI. With a background in Medical Biotechnology and Molecular Medicine, she fell in love with histopathology just to challenge it, when her research showed the current ways are not enough.IMAI is a pre-seed stage Swiss medtech startup. They develop an automated robotic platform for faster 3D analysis of tumor tissues. Supported with AI, they avoid false negatives and offer better cancer detection. Here is more about them:https://www.imai-medtech.com/Timestamps:0:00 Dr. Francesca Catto and IMAI1:11 Why Hospital Pathology Departments Did Not Go Digital2:30 What Happens to Your Biopsy: Current Gold Standard9:57 Kinds of Human Tissues and Cells11:33 What Do Cancer Cells Look Like13:52 Problems with Current Histopathology15:25 Histology Definition, Histopathology Definition, Pathology, Histotechnology16:56 Challenging the Status Quo with 3D Histology24:22 How Do You See Inside a Tissue in 3D Models28:32 Robotic AI-Powered Platform for Histopathologists40:18 400x More Cells Analysed in 3D Histopathology46:14 Thank You, Follow IMAI46:45 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

5/14/24 • 48:06

Another silent killer on the X-Health.show: diabetic neuropathy.Undetected in too many instances.Slowly taking away the balance. Implementing pain.Starting at the feet and unstoppable, if not treated.In this episode, you’ll hear aboutdiabetic neuropathy and diabetic neuropathic painthe millions of people it concernswhy the current treatment is simply not enoughwhat change wearing a smart sock for 20 minutes bringsand all these nerves connected to the brain involved in walkingMy guest today is Dr. Greta Preatoni, the CEO of MYNERVA. She’s both a neuroscientist and a neuroengineer who did her research in diabetic neuropathy. She can awesomely speak about the neural pathways involved in sensing and movement.MYNERVA is an early-stage Swiss startup, a spin-off from the ETH, Zurich. They develop a pleasant, as they emphasize, non-invasive nerve stimulation device for people with diabetic neuropathy to kill pain and walk without problems.Here is more about them:https://www.mynervamedical.com/Timestamps:0:00 Dr. Greta Preatoni and MYNERVA1:12 Diabetic Neuropathy or the Silent Killer of Millions4:50 Symptoms of Diabetic Neuropathy9:38 Neural Pathways Involved in Walking16:28 How a Sock Can Help Regain Balance and Kill Pain22:44 Reaction of the First Patients with Sensory Loss29:34 How to Use the Sock for Neuropathy32:12 Can Neuropathy Nerve Damage Be Regenerated35:47 From Science to Entrepreneurship with Family History40:09 Path to Launching Leia by MYNERVA for Diabetic Neuropathy54:04 Thank You, Follow MYNERVA55:02 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

5/8/24 • 56:23