Show cover of X-Health.show - meet the future of healthcare

X-Health.show - meet the future of healthcare

The X-Health.show brings to you brilliant minds behind programming living cells, tech that detects pre-term delivery in seconds, brain-computer interface or apps that employ AI to match you, your disease with the best treatment. For the eXtra Health of the future.You’ll meet visionaries from Switzerland who push the boundaries of healthcare. Engineers who teamed up with doctors, scientists turned CEOs, doctors programming AI-powered apps, researchers who abandoned university labs to improve your health.You’ll hear stories of promising startups founders and successful serial entrepreneurs. Patients who imagine a better way.You’ll  learn about new disease treatmentsunderstand how AI-driven health tech can improve your life grasp the way founders innovate or even, get inspired to jumpstart innovation at your company.Luckily, the X-Health.show is based in Switzerland, the most innovative country in the world according to World Intellectual Property Organization. For the 12th consecutive year. No wonder when the abundance of funds for innovation meets the ability to commercialize the discoveries.With notable research institutions situated nearby top pharmaceutical companies, there’s more to expect. More medical innovations, break-through femtech, life changing biotech, developments in digital health, genetic engineering, and  wearables, such as smart ring, blood pressure measurement on your wrist or ECG in your pyjama.Follow the show to meet these amazing innovators.

Tracks

Get Mentally Better Faster with Digital Phenotyping: Joy Bordini, Go Healthy
How long are you willing to stay in psychotherapy?Or do you want to just get better?This is what Joy wanted.To get better – faster.As a bioinformatician, she worked with big data setsand could not accept that in her psychotherapy she depended on paperwork, as if it was still the 20th century.You’ll hear in this episodewhat is digital phenotypingwhat passive digital data do you generate on your smartphonehow it can be used to support your mental wellbeing and connect a therapist with a patient betterYou will also have a better understanding of Gen Z’s mental health needs.My guest today is Joy Bordini, the CEO of Go Healthy. A powerhouse really that has a rare ability to understand both emotions and complex tech. Specializing in AI and bioinformatics, she used to perform whole genome and exome sequencing, working on complex data sets.Go Healthy & Co. is an early-stage Swiss startup that supports diagnosis and therapy response analysis in mental health by using digital phenotyping. Their software is meant for clinics and mental health providers and in the end, to serve both patients and therapists.And here’s more about Go Healthy:https://gohealthyandco.com/en/home/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
55:16 7/9/24
App for People with Diabetes to Do Sports Safely: Dr. Sam Scott, Enhance-d
Managing diabetes is complex enough, adding sports on top of it seems too much for many. But what if you had an app that would help?You’ll hear aboutthe physiology of exercising with type 1 and type 2 diabeteswhat can go wronghypoglycaemia and hiperglycaemiaketoacidosistools to use to take control of the glucose level and do sports seriously, like there weren’t out there beforeMy guest today is Dr. Sam Scott, the Chief Scientific Officer at Enhance-d. An exercise physiologist with a vast background in researching diabetes and exercise in the UK, Canada, and Switzerland. He is an Advisor on the Exercise Physiology interest group leadership team for the American Diabetes Association. He used to be the Head of Research for Team Novo Nordisk the world’s first all-diabetes professional cycling team. Enhance-d is a Swiss startup that develops an app for people with diabetes to exercise and even do professional sports safely by giving actionable, individualized insights drawn from a plethora of diabetes and exercise data.Here you may follow their Beta and finale app release:https://www.enhance-d.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
51:07 7/2/24
Getting Rid of Injections for Diabetes and Other Drugs? Dr. David Klein Cerrejon, Obaris
If you are a person with diabetes, you already know that some drugs cannot be administered other than via injections. Today’s guest works on a solution for these medications to be taken from the inside of the cheek.You’ll hear:how different kinds of drugs are absorbedwhy some drugs, macromolecular drugs, need to be delivered in injectionshow Obaris has overcome this problemhow drugs such as Ozempic or Mounjaro could be administered painlesslyDr. David Klein Cerrejon is the CEO of Obaris, a chemist with a PhD in pharmaceutical science specializing in drug delivery. Obaris is a Swiss startup, an ETH spin-off, that develops Octo-Patch, a small, painless patch, resembling an octopus sucker, that you can stick to the inner side of the cheek to administer drugs that are now available only in injections.Here is more about Obaris:https://obaris.ch/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
46:21 6/25/24
Detecting Brown Fat for Better Diabetes, Obesity and Cancer Treatment: Dr. Andrej Babic, Adiposs
The small amount of brown fat can make you slim. Too much may kill you. We just don't know who has it and how much. But this may change with this test.You’ll hear aboutbrown fat but also white fat and beige fatwhat happens when we have too much brown fat or too littlea new contrast agent to see brown fat on a CT scanthat allows targeted therapies for cancer, diabetes, obesity,and even longevityDr. Andrej Babic is the CEO of Adiposs. A pharmacist with a PhD in medicinal chemistry who developed molecules for the diagnosis of diabetes, obesity, and cancer at the University of Geneva. He holds patents in medical imaging, photodynamic therapy, and nanotechnology.Adiposs is a Swiss startup that develops ImageBAT, a first-in-class CT contrast agent for brown fat. This can be a game changer in obesity treatments, metabolic diseases, diabetes type 2, and cancer.https://adiposs.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
52:54 6/18/24
One Man's Quest to Beat Alzheimer's: Hassan Fadli, 5 Ironmans to Beat Alzheimer's
He dropped his engineering job to run 5 Ironman triathlons in 5 countriesfor a cause.But he did not foresee he would gather so many scientists on the waythat try to find a way to mitigate dementiaYou’ll hearwhat does it take to run an Ironman triathlonhow his family coped with his father’s Alzheimer’show he united several startups and researchers to launch a study on the impact of lifestyle on the epigenetic level – to mitigate dementiaMy guest today is Hassan Fadli, a materials engineer with 20 years of experience as a technology lead in the solar energy industry. But we’re not going to speak about photonics. His family history made him turn his life upside down.He’s founded "5 Ironmans to Beat Alzheimer’s”, a non-profit initiative to run 5 Ironman triathlons in 5 countries in one year. They film a documentary about it, also interviewing dementia specialists, societies, patients, and families in all these countries. After Switzerland and Portugal, there are 3 races ahead in 2024: in France, Nice – on June the 16 UPDATE: finished and beat his record!in Sweden, Kalmar – on August the 16 and Spain, Calella-Barcelona – on October the 6thFollow his Ironman races at:https://www.5ironmansbeatalzheimer.com/en If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
50:21 6/11/24
New Era of Highly Targeted Drugs Originating from the Dark Genome: Dr. Samir Ounzain, HAYA Therapeutics
Can the Dark Genome have the answer to any disease?And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating.Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases.With the potential to cure them completely.Today we are speaking about heart fibrosis and also:the richness of the regulatory genomeits function: as a kind of software for the human bodyRNA therapies that are targeted, non-toxic, fast in developmentan absolutely new approach to drugsDr. Samir Ounzain is the CEO of HAYA Therapeutics. A molecular biologist who’s researched dark genome and its roles for over 15 years. While a postdoc at Lausanne University Hospital (CHUV), he discovered hundreds of long-non-coding RNAs.HAYA Therapeutics selected one of them, called Wisper, to develop a highly targeted drug to address cardiovascular disease. That's  for starters. They already work on lung fibrosis, cancer microenvironment, liver, pancreas, and kidney.  They are based in both Lausanne and San Diego.https://www.hayatx.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
61:03 6/4/24
Tracking Your Breath to Improve Running: Dr. Patrick Helfenstein, BreezeLabs
Haven’t heard about breathing rate tracking yet?Listen up.You won’t need much:just your headset and an app.In this episode, you’ll hear abouttraining plans based on breathingteaching ML models to recognize breathing patternshuge breathing data setsand how will you be able to use them to improve your training efficiencyDr. Patrick Helfenstein is the co-founder and Chief Technical Officer at BreezeLabs. A physicist originally, with over a decade of research experience in both academia and industry he embraced Machine Learning. Just wait until he starts speaking about it. BreezeLabs is a pre-seed stage Swiss startup that promises runners better optimised training by adding breathing rate tracking. No additional wearable needed, just a headset with a mic and their AI models will do the rest.Here’s more about them:https://www.breezelabs.ai/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
47:07 5/28/24
AI-Powered Robotic Platform for Faster and More Accurate Diagnose of Cancer Biopsy Samples: Dr. Francesca Catto, IMAI
Challenging an over 100-year-old histology technic that is prone to false negatives.In cancer diagnostics.My guest aims to take histopathology departments from the 20th century into the 21st century, where they belong.From slicing biopsy samples into 3D.From a manual preparation to a robotic one.Where all abnormalities will be pointed out and counted by AI.And human physicians will see inside the whole sample in 3D.Let's get down to the cell level.You’ll hearwhat happens to your biopsy sampleswhy the current histopathology standard is prone to misseshow do you see inside the tissue in 3D and see 400 times more cellswhat’s so fascinating about watching cells and tissues under the microscopeand more Dr. Francesca Catto, the CEO of IMAI. With a background in Medical Biotechnology and Molecular Medicine, she fell in love with histopathology just to challenge it, when her research showed the current ways are not enough.IMAI is a pre-seed stage Swiss medtech startup. They develop an automated robotic platform for faster 3D analysis of tumor tissues. Supported with AI, they avoid false negatives and offer better cancer detection. https://www.imai-medtech.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
48:06 5/14/24
AI Supported Sock to Kill Diabetic Neuropathy Pain and Regain Balance: Dr. Greta Preatoni, MYNERVA
Another silent killer on the X-Health.show.Undetected in too many instances.Slowly taking away the balance. Implementing pain.Starting at the feet and unstoppable, if not treated.In this episode, you’ll hear aboutdiabetic neuropathythe millions of people it concernswhy the current treatment is simply not enoughwhat change wearing a smart sock for 20 minutes bringsand all these nerves connected to the brain involved in walkingMy guest today is Dr. Greta Preatoni, the CEO of MYNERVA. She’s both a neuroscientist and a neuroengineer who did her research in diabetic neuropathy. She can awesomely speak about the neural pathways involved in sensing and movement.MYNERVA is an early-stage Swiss startup, a spin-off from the ETH, Zurich. They develop a pleasant, as they emphasize, non-invasive nerve stimulation device for people with diabetic neuropathy to kill pain and walk without problems.https://www.mynervamedical.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
56:23 5/8/24
Replacing Chemotherapy with a Gentler Process: Dr. Danielle Villars, ATLyphe
How one approaches the goal of replacing chemotherapy with a gentler process? Where does the “we can do it” start? How do you get to the point where your process shows no side effects in the pre-clinical phase, in animals? And when will clinical trials start – in patients?In this episode, you’ll hear abouthow are blood cells producedacute myeloid leukemiahematopoietic stem cell transplantation or bone marrow transplant procedurehow to replace chemotherapy in the conditioning stageATLyphe is a Swiss Startup, a spin-off from the ETH Zurich and the University of Zurich. They developed a T cell engager and activator for safer, precise conditioning before hematopoietic stem cell transplantation in leukemia.My guest today is Dr. Danielle Villars, the CEO of ATLYphe, a biologist who completed her PhD in cancer biology. She already proved she is a high achiever – before committing to science-backed entrepreneurship and bringing this new process to patients, she broke four national records as an Olympic swimmer for Switzerland.Here’s more about ATLyphe:https://www.atlyphe.com/Please note, the treatment is not yet available for patients. If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
47:05 5/2/24
Treating Cancer with Bacteria: Dr. Ana Montalban-Arques, Recolony
A specific strain of bacteria might help prevent and even treat colorectal cancer. The studies in animals show potential in treating other cancers, too.You’ll hear abouthow many bacteria inhabit a human and how much do they weigh (I bet you underestimate their weight)what is a dysbiotic gut microbiomethe gut microbiome and its influence on colorectal cancerstudies of specific strains of bacteria that show reducing cancer in micewhat is the potential of life biotherapeutic productsMy guest today is Dr. Ana Montalban-Arques, the CEO of Recolony. Trained in molecular biology and biotechnology she researched host-microbe interactions in the gut.Recolony is a Swiss startup, a spin-off from the University of Zurich. They aim to develop a bacteria-based oral therapy to treat and prevent colorectal cancer. No chemotherapy, no side effects – oral administration at home. Please note, their treatment is in the pre-clinical phase and it means it is not yet available for patients.You may find out more about them athttps://www.recolony.ch/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
53:40 4/23/24
Keeping the Liver Alive Outside of the Human Body and Treating Diseases: Dr. Waldemar Hoffmann, Apersys
Out of 16 000 livers donated in the US, 7 000 are discarded. 14 000 patients are on the waiting list for a transplant. What if we could recondition the 7 000? What if we could treat these livers outside of a human body and transplant to the patients that need them?You’ll hearwhat’s the ideal liver graft and why there’s a shortage of themhow to keep a liver alive outside of a human bodythe possible future of growing organsand moreMy guest today is Dr. Waldemar Hoffmann, the CEO of Apersys. A bioengineer and biomedical engineer, with years of experience in medtech. Also, with years of experience in waiting with his father for a kidney transplant.Apersys is a Swiss startup that developed a perfusion machine able to preserve and recover human organs outside of the human body. What it means is, putting a discarded liver onto a machine, treating it, regenerating it, and transplanting into a patient.You may find them at https://apersys.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
50:42 4/16/24
Sleep Better Using a Breathing Biofeedback: Dr. Vincent Martinez, Oxa
What is your optimal breathing rhythm for relaxing? How to make sure it is exactly for you? How does the sensor know when you drift off and how you breathe?Today you’ll hear aboutsleep trackingbreathing exercises for anxiety, stress, panic attacksHRV or heart rate variabilityand ECG in a T-shirtsmart textilesand Alex’s experience using OxaOxa is a wearable to help you relax and fall asleep by not only tracking your heart rate but also breathing. The sensor allows live biofeedback and you only have to put a T-shirt a bra or a strap on.My guest, Dr. Vincent Martinez is the CEO of Nanoleq. An engineer who created an unbreakable cable during his PhD in biosensors and bioelectronics. This was the basis to create, with neuroscientists on board, Oxa.Find out more about Oxa athttps://oxalife.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
57:34 4/9/24
Organs on Chip – Faster and Safer Drug Development while Saving Animals from Pre-Clinical Studies: Dr. Nina Hobi, Alveolix
Take a plastic chip,a bunch of cells,add some real complex engineering and cellular biology scienceand you'll have a lung-on-chip that can breathe as if in a human body.You're ready to test drugs, as if on people, instead of miceIn this episode, you’ll hear aboutthe biology of breathing, down to the cellular level,how to better predict drug responses in humans,the difference between organoids and organs-on-chip,how does a lung-on-chip work and can you trust it,the wonderland of alveoli biology,the future with less animal testing.My guest today is Dr. Nina Hobi the CEO of AlveoliX. A molecular biologist with over a decade of research in organs-on-chip and an awesome talent for putting complicated biological processes in simple words. A compelling intuitive leader, she inspires her team and partners to keep the ball rolling. No wonder, after hours she’s a volleyball referee.AlveoliX is a Swiss startup that developed organ-on-chip technologies to make pre-clinical drug testing safer, better, and personalized while reducing animal testing. Their lung-on-chip enables human alveoli cells breathe just like they do in the human body.Find out more about AlveoliX athttps://www.alveolix.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
61:14 4/2/24
Bionic Hand: Dr. Solaiman Shokur, EPFL
You cannot underestimate the emotion when you can feel the warmth of someone’s hand in the hand you do not have.Or cold in the fingers you have not had for years.In this episode, you’ll hear abouthow people with an amputated hand, can feel the temperature in their phantom handwhy you don’t really feel wet or can be tricked into feeling wet when there’s no wetnesshow do you feel the temperatureand surelybionic handsrobotic handsneuroprosthesesMy guest, Dr. Solaiman Shokur is a neuroengineer and a scientist, a co-founder of a neurotech company working on 'nerve machine interfaces’. He worked on some real cool stuff: brain-computer interfaces – he worked in the same lab with Neuralink CTO and co-founders and he was involved in the mind-controlled robotic exoskeleton featured during the 2014 World Cup. Dr. Shokur moved then into restoring sensory-motor functions, haptics, and now, with an international team, he works on new bionic technology called MiniTouch. There are three centers involved: Translation Neural Engineering Lab at EPFL led by Prof. Silvestro Micera, Switzerland, Scuola Superiore Sant’Anna subsidiary in Pisa, INAIL institute in Bologna. MiniTouch allows a person with an amputated hand to feel hot and cold in their phantom hand.You may learn more about the lab here:https://neuro-x.epfl.ch/en/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
61:06 3/27/24
Breath Test for Diagnosing Respiratory Infections: Melanie Aregger, Avelo
Imagine breathing into a small tube for a few minutes, then your breath aerosol is sent for a PCR analysis. Quick you'll have the result: bacteria or virus causing pneumonia and can have the right treatment prescribed.You’ll hearhow tricky it is to detect bacteria and viruses in the breathwhy so many pneumonia cases are deadlywhat is an electrospun nanofiber filterhow to better diagnose tuberculosis and why so many cases go undiagnosedand moreMelanie Aregger is the CEO and co-founder of Avelo. A natural-born entrepreneur with experience in the diagnostics, medical device, and biotech industry. She recharges while running marathons in the high Alps or going on racecations – taking part in running races.Avelo is a Swiss startup that develops AveloCollect, a breath aerosol collector. They aim at detecting tuberculosis and lower respiratory tract infections, the ones that cause pneumonia – from the breath. No nasal swab, no sputum, no blood sample. Just breathe into a tube.More about Avelo:https://www.avelolife.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
47:29 3/22/24
Lab-on-Skin to Detect Sepsis Before It's Too Late: Esmeralda Megally, Xsensio
If you suddenly slide into sepsis, there’s a 50% chance you’ll survive. Because it is so hard to detect it.Lab-on-Skin works to change it. And has the Mayo Clinic on their side.Today you’ll hear aboutcontinuous shock monitoring – to detect the earliest symptoms of sepsishow to assess sepsisnanotechnology, nanoelectronics, nanofluidicsand the unexplored wealth of our interstitial fluidEsmeralda Megally is the CEO and co-founder of Xsensio. Having worked in the US on the launch of a new Investment Fund backed by the Bill & Melinda Gates Foundation, she found her entrepreneurship call in Switzerland.Xsensio is a Swiss startup, a spinoff from the Nanolab at EPFL that develops Lab-on-Skin. It’s a medical-grade wearable that tracks biochemical information for continuous remote monitoring of patients at risk – sepsis for the start. But there's way more to come.https://xsensio.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
48:44 3/12/24
New Longevity Supplement: Mitochondrial Revitalizer: Dr. Anurag Singh, Timeline
When do you think you start aging?Age-related mitochondrial decline, one of the reasons for aging, starts in your 30s and 40s.Pretty early, huh?Today you’ll hear aboutlongevity and healthy agingimproving your healthspan from the cellular levelmitophagy and how to amp it upthe power of pomegranates and berrieswhy not all of us can unleash itand why the French maintain better gut healthDr. Anurag Singh is the Chief Medical Officer at Timeline. A medical doctor and immunologist with over 15 years of clinical and translational research experience in biotech and life sciences, Nestle – among others.Timeline is a Swiss biotech company that patented a “mitochondrial revitalizer”, a molecule called Urolithin A. Their Mitopure – in the form of an oral supplement or a facial cream – showed in trials improved muscle strength, faster recovery, and more collagen in the skin.https://www.timelinenutrition.com/Timestamps0:00 Dr. Anurag Singh and Timeline1:11 Why Do We Age? 12 Biological Processes That Slow Down with Aging2:34 Mitochondrial Renewal to Slow Aging11:18 The Power of Pomegranates and Urolithin A17:56 What Are Urolithin A Effects in Humans31:33 How Postbiotic Mitopure Amps Up Mitophagy48:24 How Does Urolithin A Work in a Face Cream52:44 Dosage for Longevity56:03 Availability and Growth Plans1:01:35 Thank You, Follow Timeline1:02:00 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
63:20 3/5/24
Testing for Biological Age to Increase Healthspan: Dr. Semira Gonseth Nusslé, Genknowme
Older biological age is associated with higher mortality and various age-related diseases.What can you do if you know that you look older, feel older, are older biologically than the date of birth on your passport? What can you do with your test biological age?You’ll hear aboutlongevity and healthspanchronological vs biological agewhat is an epigenetic clockhow to measure biological agewhat happens in your epigenome when you drink alcohol, smoke, or sit too longDr. Semira Gonseth Nusslè is a co-founder and Chief Medical Officer at Genknowme. A medical doctor by training she joined the pioneers in epigenetic epidemiology at the University of California San Francisco and got real hooked. She awesomely explains the inside-outs of epigenetics, DNA, down to DNA methylation measuring.Genknowme is a Swiss startup that developed an epigenomic test for biological age that not only motivates better to change your harmful lifestyle but also can track changes for the better (or worse).https://genknowme.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
48:52 2/27/24
VR and AI Eye Examinations for Glaucoma: Prof. Raphael Sznitman, Perivision
If you miss your glaucoma appointment in the UK, you could partially go blind while waiting for the next one. How about taking the test by yourself at home with a VR headset?You’ll hear aboutwhy banging into objects can be both glaucoma early symptoms, and late oneswhy many people don’t even realize they have glaucomahow glaucoma is diagnosed now, why it is so frustratinghow coffee can impact your visual field examinationsa VR headset paired with Machine Learning connected to your ophthalmologistProf. Raphael Sznitman is a co-founder of Perivision. A computer scientist and biomedical engineer who works closely with clinicians on AI solutions in ophthalmology.Perivision is a Swiss startup, a spin-off from the University of Bern. Their eye test headset uses Virtual Reality, cloud computing, and AI to test for glaucoma and the visual field. It reduces the test time by up to 70%.https://www.perivision.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
53:31 2/20/24
Computer Vision to Diagnose Cancer on a Blood Smear: Prof. Christian Ruiz, Moonlight AI
Instead of or before a genetic test – a blood smear analysis to detect blood cancers might soon be an option.What a human eye cannot see – also under a microscope, computer vision + AI can.You’ll hear aboutcancer diagnostics in highly specialized centerswhy is Next-Generation Sequencing so expensivehow AI and computer vision can help bring personalized cancer medicine to millions of patientshow to train algorithms to recognize genomic aberrationsProf. Christian Ruiz is the Chief Scientific Officer at Moonlight AI. As a professor of experimental medicine at the University of Basel and used to be responsible for a diagnostic laboratory at the University Hospital Basel which processes more than 100,000 biopsies a day.Moonlight AI is an early-stage Swiss startup that developed a platform to detect genomic aberrations in blood cancers by analyzing the image of a blood smear. This will allow targeted therapies for leukemias and lymphomas at a fraction of the current cost.https://www.moonlight-ai.com/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
44:37 2/9/24
How Radiologists Can Predict Osteoporosis Before It Breaks Your Bones: Prof. Didier Hans, Medimaps Group
You don't see your bones melting in a hot bath, so usually osteoporosis is diagnosed too late. 20% of people with an osteoporotic fracture will die within a year. 1 woman out of 2 will develop osteoporosis after menopause1-2 men out of 5 will develop osteoporosisbut more men die of the consequences of osteoporosis Now, this can change. You may act against it earlier.You’ll hear abouttil what age you build your bone masswhat is osteoporosis and how to diagnose ithow to predict osteoporotic fracture risk years before it happensto buy you time and prevent itProf. Didier Hans is the CEO of Medimaps Group. A medical physicist with over 25 years of experience in dual-energy X-ray bone architecture ultrasound imaging techniques. He can talk hours about osteoporosis and bone and body composition.Medimaps Group is a Swiss scaleup that developed TBS iNsight, software that in 3 seconds adds Trabecular Bone Score (hence TBS) to the regular DEXA bone screening and helps detect an additional 30% of patients at osteoporotic fracture risk.https://www.medimapsgroup.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
76:12 1/31/24
How to Measure Gut Microbiome to Keep It in Balance: Dr. Paulo Refinetti, REM Analytics
There is a small family of bacteria inhabiting your gut that have a super important role to play: activate vitamin B6, regulate obesity, improve your mood, reduce anxiety and stress.You’ll hear aboutgut microbiome balance, how to achieve it, and how to kill itthis small family of gut bacteria, namely Bifidobacteriathe role of Bifidobacteria in preterm and full-term infants and in obese teenagerswhat is the difference between probiotics, prebiotics, postbiotics, and symbioticstests that measure the number of your gut Bifidobacteriaand the tests can bring us closer to preventive medicine  Dr. Paulo Refinetti is a bioengineer and a statistician who completed his Ph.D. at both Swiss EPFL and MIT. He lights up when speaking about the tech they develop to test the Bifidobacteria and about large batches of vanilla and cinnamon sticks he buys from Uganda and Sri Lanka.REM Analytics is a Swiss startup that develops novel tests to analyze the microbiome. They can measure the colonization of specific probiotic strains in human microbiome and differences induced by changes in food and lifestyle.https://www.remanalytics.ch/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
48:24 1/17/24
Revolutionizing Access to Ground-Breaking Clinical Trials for Cancer Patients: Danielle Ralic, Ancora.ai
To search for a possibly life-saving ground-breaking treatment for a cancer patient that is available only in clinical trials it takes: personal connections your oncologist network long hours frustration and luck.Ancora.ai wants to change it.Make clinical trials and innovative treatments more accessible for patients.Accelerate the search for patients for clinical trial sponsors.It takes around 5 minutes with Ancora.ai platform to search for possibly relevant clinical trials for cancer patients. But it is not the end of the story.You’ll hear aboutwhy and when to consider a clinical trial if you’re a cancer patienthow to find a relevant trialwhy currently it is so frustrating for both those who run them and patientshow tech paired with motivated humans can helpThe Founder and CEO of Ancora.ai Danielle Ralic is on a mission to bring treatments available in breakthrough clinical studies to cancer patients. She’s a technologist who used to develop analytics solutions for Pharmaceutical and Healthcare organizations. Motivated by both what she experienced professionally and in her private life while trying to search for treatments for her friends and family. Ancora.ai is a Swiss startup that developed an AI-powered platform where cancer patients and their loved ones can search for available trials in a matter of minutes.Here is the platform:https://www.ancora.ai If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
58:42 1/10/24
Blood Vessel Organoids for Cruelty-Free Drug and Cosmetics Testing: Dr. Paul Bradfield, MesenFlow
A drug that works for a mouse might not work for a human. How about testing drugs for inflammatory diseases – and cosmetics – on human organoids? You’ll hear what are human vascular organoidsand how to grow human cellsalso about the mechanisms of inflammation and the ability to see where drugs can block itarthritis and other chronic inflammatory diseasespersonalized medicinecosmetics not tested on animalsa terrifying process of founding a startupa death, a theft, a fire, and an obsessive mindset that kept the lab standingDr. Paul Bradfield is a scientist turned an efficient CEO. An expert in drug development and assay development, he has specialized in inflammatory diseases. After laboratory head at Merck Serono, he took an entrepreneurship path and founded MessenFlow.MessenFlow is a Swiss scale-up that has developed a platform for animal-free accelerated drug and cosmetics development. Their human tissue engineering system mimics human inflammation and allows us to, literally, see the movement of leukocytes in blood vessels.Here are more details about what the lab can do:http://mesenflow.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
61:48 1/3/24
Off-the-Shelf Scalable Cell Therapies to Cure Cancer, HIV, and More: Dr. Marco Alessandrini, Antion Biosciences
If you heard about miraculous CAR-T cell therapies that cure cancer in one go, my guest today works on something one step further: immunotherapies that are manufactured from healthy donor cells. That means a thousand cancer patients may receive in the future a life-saving shot manufactured ahead and administered when needed.You may expect a fascinating journey into off-the-shelf cell immune therapies of the futurehow the HIV virus works and how understanding this is key to the novel therapythe difference between gene editing and gene engineeringwhat is gene silencingwhat is microRNAand how to administer immune cells from a donor without creating immunowarsDr. Marco Alessandrini is the CEO of Antion Biosciences. A biochemist and molecular biologist who aims to democratize access to mind-boggling (and very expensive now) cell therapies. A seasoned researcher who beautifully talks about gene and cell engineering.Antion Biosciences is a Swiss biotech startup developing novel gene and gene-modified therapies thanks to a proprietary multiplex cell engineering platform. Their miCAR T cells are manufactured – hold your breath – from a healthy donor to treat a thousand cancer patients. They are at the beginning of this very promising journey.https://antionbio.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
56:17 12/27/23
Growing Bone Organoids to Test Bone Cancer Drugs on Cells Before Administering Them to Patients: Dr. Gian Nutal Schädli, CompagOs
While growing bone organoids, it is apparently important to take bone cells to the gym three times a week. Or – apply mechanical loading, if you want to use more precise language. You’ll hear aboutmechanical properties of the human bonehow to grow bone organoids and what can you test on themosteogenesis imperfecta called glass bonesosteosarcomabone metastasisand bone density in Roger Federer's right wristDr. Gian Nutal Schädli, the CEO of CompagOs, completed his PhD in biomechanical engineering with the focus on bone organoids. Fun fact his middle name – Nutal – means Christmas in Romansh, the fourth language of Switzerland.CompagOs is a Swiss startup a super fresh ETH spin-off. They aim to help clinicians and drug developers choose the most effective treatment for patients with bone cancers. Their mineralized 3D bioprinted bone organoids closely mimic natural bone structures.Follow them onhttps://www.compagos.ch If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
49:04 12/20/23
The Smallerst Health Tracker Ring So Far: Dr. Antonino Caizzone, Velia Smart Ring
A new wearable is coming to the market in 2024: a smaller ring to track your sleep, stress, calories burnt, and other vitals and activities. Already pre-ordered by over 7000 people .You’ll hear abouta smart ring that is smaller than other rings and what fits insidewhat can you track with itthe differences between various wearables: smartwatches, ringshow does PPG technology work and how small the sensors can behow to earn trust and raise substantial funds with crowdfundingand also, how to act as a zebra if there are big players around the same technology and you're just a startupDr. Antonino Caizzone is an engineer specializing in microengineering and nanotechnologies, especially sensors, with experience working on wearables.Velia Smart Ring is the first product develped by Senbiosys, a Swiss startup, a spinoff of the Swiss Federal Institute of Technolology (EPFL). It is the smallest, at the time of this recording, ring to track your health and wellness. Thanks to the crowdfunding campaign that raised so far over 1.7 MLN dollars they’re on the way to launch the ring at the beginning of 2024.You can still preorder the ring athttps://www.indiegogo.com/projects/velia-smart-ring-ex-iris#/And have some more info about the company athttps://www.senbiosys.com/velia/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
58:27 12/13/23
AI-Guided Tracheal Intubation Procedure. Who's Ready for Robotic Intubation: Philippe Ganz, aiEndoscopic
Could a robot perform trachea intubation? How about letting AI guide clinicians and paramedics in inserting the tube into people's airways?You’ll hearwhat is tracheal intubation and why it is far from putting a straw in a bottlewhat can go tragically wronghow long do anaestesiologists perfect the skill and how much less some other specializations have traininghow to train AI in intubationcan a robot do the joband also, Alex's attempt to intubate a manekinPhilippe Ganz is the CEO and co-founder of aiEndoscopic. With background in aeronautical engineering he switched to physics that he found too theoretical and ended up happily with biomedical engineering.aiEndoscopic is a Swiss seed-stage startup that developed larynGuide an AI assisted guiding software for safer video laryngoscopy. Think: guided tracheal intubation for beginners. A fully robotic solution, IntuBot, comes next. And they do not stop there.Find them at aiendoscopic.com If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
49:58 12/6/23
Developing New T Cell Immunotherapies for Difficult Solid Tumors: Prof. George Coukos, Department of Oncology UNIL-CHUV
Have a glimpse into the future of cancer treatment where an army of your own tiny soldiers fiercely combats the most stubborn cancers, even at late stage. They’re called T cells. My today’s guest has worked on immunotherapies that arm T cells, patient’s own white blood cells with weapons agains tumors to infuse them back to the patient’s body.Whether you’re an oncologist or a nonspecialist, you may be sure you’ll learn a tonne from this episode.You’ll hear abouthow tumors suppress anti-cancer immune responsewhy solid tumors in ovarian cancer, colon cancer, gastro-intestinal cancer, pancreatic cancer, and some breast cancers are more challenging for immunotherapiesmelanoma, lung cancerTIL therapiesadoptive T cell therapiesautologous dendritic cell vaccineand patient experienceProfessor George Coukos is on a mission to find a cure for the most difficult cancers. Trained as an MD and obstetrician-gynaecologist, he studied and researched cell biology and oncology at the University of Pennsylvania, which led to the discovery of spontaneous anti-tumor response in ovarian cancer. Now he leads major oncology research institutions in Lausanne, Switzerland, to develop novel T cell therapy approaches for solid tumors. He’s the director of Department of Oncology at the University of Lausanne (UNIL) and Lausanne University Hospital (CHUV), as well as the local branch of Ludwig Institute for Cancer Research. An esteemed researcher with over 200 publications, known for the development of combinational immune therapies that have been approved for lung, liver, and kidney cancers.To follow Prof. Coukos and his colleagues' recent developments go to https://www.unil.ch/dof/home.htmlhttps://www.ludwigcancerresearch.org/location/lausanne/ If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
76:05 11/29/23